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Protein Ontology Report - hMYD88

PR:Q99836 - http://purl.obolibrary.org/obo/PR_Q99836
This page represents a class of proteins encompassing all the protein products of the MYD88 gene in human .
Ontology Information
PRO ID PR:Q99836 Show OBO stanza / PAF
PRO name myeloid differentiation primary response protein MyD88 (human)
Alternate ID PR:000025770
Synonyms
PRO-short-label: hMYD88
Definition A myeloid differentiation primary response protein MyD88 that is encoded in the genome of human. [PRO:CNA]
PRO Category organism-gene
Parent PR:000001740 myeloid differentiation primary response protein MyD88
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 8
organism-modification 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hMYD88 forms found in complexes
hMYD88 Component Complexes
PR:000001740 MYD88 PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:000001740 MYD88 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:Q99836 hMYD88 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:Q99836-1 hMYD88/iso:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:Q99836-1 hMYD88/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:Q99836-1 hMYD88/iso:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000001740
MYD88
has_part Pfam:PF01582 TIR domain
has_part Pfam:PF00531 Death domain
PR:000027183
IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027192
pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034142 toll-like receptor 4 signaling pathway PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

Reactome:REACT_6894

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