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Protein Ontology Report - IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

PR:000027183 - http://purl.obolibrary.org/obo/PR_000027183
Ontology Information
PRO ID PR:000027183 Show OBO stanza / PAF
PRO name IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
Synonyms
EXACT: IRAK4:MyD88:Mal:activated TLR4 (human)
Definition An IRAK4:MYD88:TIRAP:activated TLR4 complex that is composed of activated TLR4 receptor, the long isoform of MyD88, Tirap/Mal, and IRAK4 in human. [PMID:12297423, PRO:CNA]
PRO Category organism-complex
Parent PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000027183 PR:Q99836-1 myeloid differentiation primary response protein MyD88 isoform 1 (human) hMYD88/iso:1 A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:P58753-1 Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human) hTIRAP/iso:1 A Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 that is encoded in the genome of human. [PRO:CNA]
PR:000025786 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human) hLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:Q9Y6Y9-1, 19-160, Asn-26/Asn-114, MOD:00160. [PMID:11593030, PMID:11706042, PMID:17569869, TLR:AMM]
PR:000027184 interleukin-1 receptor-associated kinase 4 unmodified form (human) hIRAK4/UnMod An interleukin-1 receptor-associated kinase 4 unmodified form in human. [PRO:CNA]
PR:000025787 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human) hTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 in human. UniProtKB:O00206-1, 24-839, Asn-35/Asn-173/Asn-205/Asn-282/Asn-309/Asn-497/Asn-526/Asn-575/Asn-624, MOD:00160. [PMID:11706042, PMID:19252480]
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1]


Functional Annotation
PRO Term GO Annotation Evidence
PR:000027183
IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034142 toll-like receptor 4 signaling pathway PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894

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