[Term]
id: PR:000001740
name: myeloid differentiation primary response protein MyD88
def: "A protein that is a translation product of the human MYD88 gene or a 1:1 ortholog thereof. This protein is an adapter involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response." [PMID:9575168, PRO:CNA]
comment: Category=gene.
synonym: "MYD88" EXACT PRO-short-label [PRO:DNx]
xref: PIRSF:PIRSF037756
is_a: PR:000000001 ! protein

[Term]
id: PR:000001742
name: myeloid differentiation primary response protein MyD88 sequence variant L93P (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that has a Pro residue at the position equivalent to Leu-93 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Leu-93, CHEBI:50342." [PMID:18669862, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence. Note: This residue is located within the Death domain. Results in a loss of function.
synonym: "hMYD88/var:L93P" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99836-1, Leu-93, CHEBI:50342" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "myeloid differentiation primary response protein MyD88 sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_047953
xref: Reactome:R-HSA-5602612 "PR:000001742 located_in GO:0005829"
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000001743
name: myeloid differentiation primary response protein MyD88 sequence variant R196C (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that has a Cys residue at the position equivalent to Arg-196 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Arg-196, CHEBI:29950." [PMID:18669862, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence. Note: This residue is located within the TIR domain. The indicated mutation results in a loss of function.
synonym: "hMYD88/var:R196C" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99836-1, Arg-196, CHEBI:29950" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "myeloid differentiation primary response protein MyD88 sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_047954
xref: Reactome:R-HSA-5602329 "PR:000001743 located_in GO:0005829"
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99836
name: myeloid differentiation primary response protein MyD88 (human)
def: "A myeloid differentiation primary response protein MyD88 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-gene.
synonym: "MYD88" RELATED Gene-based [UniProtKB:Q99836]
synonym: "hMYD88" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836
xref: Reactome:R-HSA-193946 "PR:Q99836 located_in GO:0005829"
xref: Reactome:R-HSA-166059 "PR:Q99836 located_in GO:0005829"
xref: Reactome:R-HSA-937017 "PR:Q99836 located_in GO:0005886"
xref: Reactome:R-HSA-975123 "PR:Q99836 located_in GO:0010008"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001740 ! myeloid differentiation primary response protein MyD88
relationship: has_gene_template HGNC:7562 ! MYD88 (human)

[Term]
id: PR:Q99836-6
name: myeloid differentiation primary response protein MyD88 isoform h6 (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-6." [PRO:DNx, UniProtKB:Q99836]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-6
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99836-4
name: myeloid differentiation primary response protein MyD88 isoform h4 (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-4." [PRO:DNx, UniProtKB:Q99836]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-4
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99836-5
name: myeloid differentiation primary response protein MyD88 isoform h5 (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-5." [PRO:DNx, UniProtKB:Q99836]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-5
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99836-2
name: myeloid differentiation primary response protein MyD88 isoform 2 (human)
def: "A myeloid differentiation primary response protein MyD88 isoform 2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000024846 ! myeloid differentiation primary response protein MyD88 isoform 2

[Term]
id: PR:Q99836-3
name: myeloid differentiation primary response protein MyD88 isoform h3 (human)
def: "A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-3." [PRO:DNx, UniProtKB:Q99836]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-3
is_a: PR:Q99836 ! myeloid differentiation primary response protein MyD88 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q99836-1
name: myeloid differentiation primary response protein MyD88 isoform 1 (human)
def: "A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMYD88/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99836-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001741 ! myeloid differentiation primary response protein MyD88 isoform 1