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Protein Ontology Report - IRAK4

PR:000001780 - http://purl.obolibrary.org/obo/PR_000001780
Ontology Information
PRO ID PR:000001780 Show OBO stanza / PAF
PRO name interleukin-1 receptor-associated kinase 4
Synonyms
PRO-short-label: IRAK4
EXACT: IRAK-4; renal carcinoma antigen NY-REN-64
Definition A protein that is a translation product of the human IRAK4 gene or a 1:1 ortholog thereof. The archetypical form consists of an N-terminal Death domain (Pfam:PF00531) and a C-terminal Protein kinase domain (Pfam:PF00069). This protein is an essential component of innate immunity. [PMID:11960013, PMID:16177054, PRO:CNA]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 1 organism-sequence 4
modification 3 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

IRAK4 forms found in complexes
IRAK4 Component Complexes
PR:000001780 IRAK4 PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:000027181 mIRAK4/UnMod PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027181 mIRAK4/UnMod PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027181 mIRAK4/UnMod PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:000027184 hIRAK4/UnMod PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027191 hIRAK4/iso:1/Phos:1 PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:000027191 hIRAK4/iso:1/Phos:1 PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:Q8R4K2 mIRAK4 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000027183
IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000027192
pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000001780
IRAK4
has_part Pfam:PF00069 Protein kinase domain
has_part Pfam:PF00531 Death domain
PR:000027495
pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
participates_in GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034142 toll-like receptor 4 signaling pathway PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)

Reactome:REACT_6894
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)

Reactome:REACT_6894

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