[Term]
id: PR:Q05652
name: serine/threonine-protein kinase pelle (fruit fly)
def: "An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of fruit fly." [OMA:Q05652, PRO:DNx]
comment: Category=organism-gene.
synonym: "pll" RELATED Gene-based [UniProtKB:Q05652]
synonym: "CG5974" RELATED Gene-based [UniProtKB:Q05652]
synonym: "fly-IRAK4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q05652
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000001780 ! interleukin-1 receptor-associated kinase 4
relationship: has_gene_template FlyBase:FBgn0010441 ! pll (fruit fly)

[Term]
id: PR:Q9NWZ3-1
name: interleukin-1 receptor-associated kinase 4 isoform 1 (human)
def: "An interleukin-1 receptor-associated kinase 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hIRAK4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NWZ3-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027188 ! interleukin-1 receptor-associated kinase 4 isoform 1

[Term]
id: PR:P27450-1
name: probable serine/threonine-protein kinase CST isoform 1 (Arabidopsis thaliana)
def: "A probable serine/threonine-protein kinase CST (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27450-1." [PRO:DNx, UniProtKB:P27450]
comment: Category=organism-sequence.
synonym: "At-IRAK4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P27450-1
is_a: PR:P27450 ! probable serine/threonine-protein kinase CST (Arabidopsis thaliana)
relationship: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana

[Term]
id: PR:Q8R4K2-1
name: interleukin-1 receptor-associated kinase 4 isoform 1 (mouse)
def: "An interleukin-1 receptor-associated kinase 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mIRAK4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8R4K2-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027188 ! interleukin-1 receptor-associated kinase 4 isoform 1

[Term]
id: PR:000048046
name: interleukin-1 receptor-associated kinase 4 phosphorylated 1 (human)
def: "An interleukin-1 receptor-associated kinase 4 (human) that has been post-translationally modified to include phosphothreonine at positions 342 and 345, and phosphoserine at position 346 of the amino acid sequence represented by UniProtKB:Q9NWZ3. UniProtKB:Q9NWZ3, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PRO:DNx, Reactome:R-HSA-446649, Reactome:R-HSA-936957, Reactome:R-HSA-975149]
comment: Category=organism-modification.
synonym: "hIRAK4/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9NWZ3, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-936957 "PR:000048046 located_in GO:0005886"
xref: Reactome:R-HSA-975149 "PR:000048046 located_in GO:0010008"
xref: Reactome:R-HSA-446649 "PR:000048046 located_in GO:0005829"
is_a: PR:Q9NWZ3 ! interleukin-1 receptor-associated kinase 4 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P27450
name: probable serine/threonine-protein kinase CST (Arabidopsis thaliana)
def: "An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]
comment: Category=organism-gene.
synonym: "CST" RELATED Gene-based [UniProtKB:P27450]
synonym: "CX32" RELATED Gene-based [UniProtKB:P27450]
synonym: "KIN4" RELATED Gene-based [UniProtKB:P27450]
synonym: "At-IRAK4" EXACT PRO-short-label [PRO:DNx]
synonym: "At4g35600" RELATED Gene-based [UniProtKB:P27450]
synonym: "F8D20.110" RELATED Gene-based [UniProtKB:P27450]
synonym: "protein CAST AWAY (Arabidopsis thaliana)" EXACT [UniProtKB:P27450]
xref: UniProtKB:P27450
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000001780 ! interleukin-1 receptor-associated kinase 4
relationship: has_gene_template Araport:AT4G35600 ! CST (Arabidopsis thaliana)

[Term]
id: PR:Q9NWZ3-2
name: interleukin-1 receptor-associated kinase 4 isoform h2 (human)
def: "An interleukin-1 receptor-associated kinase 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NWZ3-2." [PRO:DNx, UniProtKB:Q9NWZ3]
comment: Category=organism-sequence.
synonym: "hIRAK4/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9NWZ3-2
is_a: PR:Q9NWZ3 ! interleukin-1 receptor-associated kinase 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000027188
name: interleukin-1 receptor-associated kinase 4 isoform 1
def: "An interleukin-1 receptor-associated kinase 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NWZ3-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "IRAK4/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001780 ! interleukin-1 receptor-associated kinase 4

[Term]
id: PR:Q8R4K2
name: interleukin-1 receptor-associated kinase 4 (mouse)
def: "An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of mouse." [OMA:Q8R4K2, PRO:CNA]
comment: Category=organism-gene.
synonym: "Irak4" RELATED Gene-based [UniProtKB:Q8R4K2]
synonym: "mIRAK4" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAK-4 (mouse)" EXACT []
xref: UniProtKB:Q8R4K2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000001780 ! interleukin-1 receptor-associated kinase 4
relationship: has_gene_template MGI:2182474 ! Irak4 (mouse)

[Term]
id: PR:000001780
name: interleukin-1 receptor-associated kinase 4
def: "A protein that is a translation product of the human IRAK4 gene or a 1:1 ortholog thereof. The archetypical form consists of an N-terminal Death domain (Pfam:PF00531) and a C-terminal Protein kinase domain (Pfam:PF00069). This protein is an essential component of innate immunity." [PMID:11960013, PMID:16177054, PRO:CNA]
comment: Category=gene.
synonym: "IRAK4" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAK-4" EXACT []
synonym: "renal carcinoma antigen NY-REN-64" EXACT []
xref: IUPHARobj:2045
xref: PANTHER:PTHR24419:SF428
xref: PIRSF:PIRSF038189
is_a: PR:000000001 ! protein

[Term]
id: PR:000027190
name: interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1
def: "An interleukin-1 receptor-associated kinase 4 isoform 1 that has been phosphorylated by autocatalysis within the kinase activation loop following activation of the Toll-like receptor pathways. Example: UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PRO:CNA]
comment: Category=modification.
synonym: "IRAK4/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "activated IRAK4 isoform 1" EXACT []
is_a: PR:000027188 ! interleukin-1 receptor-associated kinase 4 isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q9NWZ3
name: interleukin-1 receptor-associated kinase 4 (human)
def: "An interleukin-1 receptor-associated kinase 4 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-gene.
synonym: "IRAK4" RELATED Gene-based [UniProtKB:Q9NWZ3]
synonym: "hIRAK4" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAK-4 (human)" EXACT []
synonym: "renal carcinoma antigen NY-REN-64 (human)" EXACT [UniProtKB:Q9NWZ3]
xref: UniProtKB:Q9NWZ3
xref: DTO:03100193
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000001780 ! interleukin-1 receptor-associated kinase 4
relationship: has_gene_template HGNC:17967 ! IRAK4 (human)

[Term]
id: PR:000027191
name: interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
def: "An interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 in human. UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046." [PMID:17141195, PRO:CNA]
comment: Category=organism-modification.
synonym: "hIRAK4/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9NWZ3-1, Thr-342/Thr-345, MOD:00047|Ser-346, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027190 ! interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000027180
name: interleukin-1 receptor-associated kinase 4 unmodified form
def: "An interleukin-1 receptor-associated kinase 4 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:CNA]
comment: Category=modification.
synonym: "IRAK4/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000001780 ! interleukin-1 receptor-associated kinase 4
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:000027181
name: interleukin-1 receptor-associated kinase 4 unmodified form (mouse)
def: "An interleukin-1 receptor-associated kinase 4 unmodified form in mouse." [PRO:CNA]
comment: Category=organism-modification.
synonym: "mIRAK4/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027180 ! interleukin-1 receptor-associated kinase 4 unmodified form

[Term]
id: PR:000027177
name: interleukin-1 receptor-associated kinase 4 phosphorylated form (mouse)
def: "An interleukin-1 receptor-associated kinase 4 phosphorylated form in mouse." [PMID:17312103, PRO:CNA]
comment: Category=organism-modification.
synonym: "mIRAK4/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027176 ! interleukin-1 receptor-associated kinase 4 phosphorylated form

[Term]
id: PR:000027176
name: interleukin-1 receptor-associated kinase 4 phosphorylated form
def: "An interleukin-1 receptor-associated kinase 4 that includes at least one phosphorylated residued after IL-1 stimulation." [PMID:17312103, PRO:CNA]
comment: Category=modification.
synonym: "IRAK4/PhosRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "IRAK-4 phosphorylated" EXACT []
is_a: PR:000001780 ! interleukin-1 receptor-associated kinase 4

[Term]
id: PR:000027184
name: interleukin-1 receptor-associated kinase 4 unmodified form (human)
def: "An interleukin-1 receptor-associated kinase 4 unmodified form in human." [PRO:CNA]
comment: Category=organism-modification. Note: The Reactome cross-references are specifically for the unmodified form, as it is the input for an autophosphorylation. [PRO:DAN]
synonym: "hIRAK4/UnMod" EXACT PRO-short-label [PRO:DNx]
xref: Reactome:R-HSA-166081 "PR:000027184 located_in GO:0005829"
xref: Reactome:R-HSA-937051 "PR:000027184 located_in GO:0005886"
xref: Reactome:R-HSA-975167 "PR:000027184 located_in GO:0010008"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027180 ! interleukin-1 receptor-associated kinase 4 unmodified form