iPTMnet Report for Q9Y6I4 (USP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6I4 / UBP3_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 3
Gene Name Name: USP3
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6I4
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 3 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 3 that is encoded in the genome of human.
Short Label hUSP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6I4 (USP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S23 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
K107 Sumoylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K354 Methylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 N37 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K59 Q59 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S124 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K132 T132 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T141 A141 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S210 G210 Biomuta DOID:363 / uterine cancer [ icgc ]
K354 N354 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S363 L363 Biomuta DOID:4159 / skin cancer [ cosmic ]