iPTMnet Report Q9Y5Z0 BACE2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9Y5Z0 / BACE2_HUMAN
Protein Name	Beta-secretase 2 precursor
Gene Name	Name: BACE2 Synonyms:AEPLC,ALP56,ASP21;ORFNames:CDA13,UNQ418/PRO852;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9Y5Z0 DAG View
PRO Name	beta-secretase 2 (human)
Definition	A beta-secretase 2 that is encoded in the genome of human.
Short Label	hBACE2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9Y5Z0 (BACE2) as Substrate

Condensed View

Search:

	Site Select all By amino acid All Serine All Threonine All Tyrosine By position T46 S70 Y93 S136 T137 S140 Y295 K299 S368 S511	PTM Type Select all O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme Select all	Score Select all 1	Source Select all GlyGen PhosphoSitePlus	PMID
	T46	O-Glycosylation		score1	GlyGen	25813380
	S70	O-Glycosylation		score1	GlyGen	30459171
	Y93	Phosphorylation		score1	PhosphoSitePlus
	S136	Phosphorylation		score1	PhosphoSitePlus
	T137	Phosphorylation		score1	PhosphoSitePlus
	S140	Phosphorylation		score1	PhosphoSitePlus
	Y295	Phosphorylation		score1	PhosphoSitePlus
	K299	Ubiquitination		score1	PhosphoSitePlus
	S368	Phosphorylation		score1	PhosphoSitePlus
	S511	Phosphorylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Tyrosine By position Y295	PTM Type Select all Phosphorylation	PTM Enzyme Select all	Score Select all 0	Source Select all HPRD	PMID
	Y295	Phosphorylation		score0	HPRD	20058876

Search:

	Site Select all By amino acid All Tyrosine By position Y295	PTM Type Select all Phosphorylation	PTM Enzyme Select all	Score Select all 0	Source Select all HPRD	PMID
	Y295	Phosphorylation		score0	HPRD	20058876

Search:

	Site Select all By amino acid All Tyrosine By position Y295	PTM Type Select all Phosphorylation	PTM Enzyme Select all	Score Select all 0	Source Select all HPRD	PMID
	Y295	Phosphorylation		score0	HPRD	20058876

Q9Y5Z0 (BACE2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

	Substrate Select all P05067-4 (APP)	Site Select all By amino acid All Threonine By position T668	Score Select all 2	Source Select all HPRD	PMID
	P05067-4 (APP)	T668	score2	HPRD	8764598, 15178331, 10936190

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position T137 S511	Variant Select all A137 F511	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:3571 / liver cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T137	A137	Biomuta		DOID:3571 / liver cancer [ cosmic ]
S511	F511	Biomuta		DOID:4159 / skin cancer [ cosmic ]