Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y5Z0 / BACE2_HUMAN
Protein Name Beta-secretase 2 precursor
Gene Name Name: BACE2
Synonyms:AEPLC,ALP56,ASP21;ORFNames:CDA13,UNQ418/PRO852;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y5Z0
DAG View
PRO Name beta-secretase 2 (human)
Definition A beta-secretase 2 that is encoded in the genome of human.
Short Label hBACE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y5Z0 (BACE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S70 O-Glycosylation GlyGen 30459171
Y93 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T137 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y295 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
Y295 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
Y295 Phosphorylation HPRD 20058876


Q9Y5Z0 (BACE2) as PTM Enzyme



Substrate Site Score Source PMID
P05067-4 (APP) T668 HPRD 8764598, 15178331, 10936190


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T137 A137 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]