iPTMnet Report Q9Y5Z0 BACE2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9Y5Z0 / BACE2_HUMAN
Protein Name	Beta-secretase 2 precursor
Gene Name	Name: BACE2 Synonyms:AEPLC,ALP56,ASP21;ORFNames:CDA13,UNQ418/PRO852;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9Y5Z0 DAG View
PRO Name	beta-secretase 2 (human)
Definition	A beta-secretase 2 that is encoded in the genome of human.
Short Label	hBACE2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9Y5Z0 (BACE2) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T46	O-Glycosylation		score1	GlyGen	25813380
	S70	O-Glycosylation		score1	GlyGen	30459171
	Y93	Phosphorylation		score1	PhosphoSitePlus
	S136	Phosphorylation		score1	PhosphoSitePlus
	T137	Phosphorylation		score1	PhosphoSitePlus
	S140	Phosphorylation		score1	PhosphoSitePlus
	Y295	Phosphorylation		score1	PhosphoSitePlus
	K299	Ubiquitination		score1	PhosphoSitePlus
	S368	Phosphorylation		score1	PhosphoSitePlus
	S511	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y295	Phosphorylation		score0	HPRD	20058876

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y295	Phosphorylation		score0	HPRD	20058876

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y295	Phosphorylation		score0	HPRD	20058876

Q9Y5Z0 (BACE2) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P05067-4 (APP)	T668	score2	HPRD	8764598, 15178331, 10936190

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T137	A137	Biomuta		DOID:3571 / liver cancer [ cosmic ]
S511	F511	Biomuta		DOID:4159 / skin cancer [ cosmic ]