iPTMnet Report for Q9Y572 (RIPK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y572 / RIPK3_HUMAN
Protein Name Receptor-interacting serine/threonine-protein kinase 3
Gene Name Name: RIPK3
Synonyms:RIP3;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y572
DAG View
PRO Name receptor-interacting serine/threonine-protein kinase 3 (human)
Definition A receptor-interacting serine/threonine-protein kinase 3 that is encoded in the genome of human.
Short Label hRIPK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y572 (RIPK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29883609
S199 Phosphorylation PRO   UniProt 11734559, 19524512
S199 Phosphorylation Q9Y572 (RIPK3) UniProt 11734559
T224 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P   UniProt 29883609, 30237400, 36342164, ...22265413, 35739084, 28454582
S227 Phosphorylation Q9Y572 (RIPK3) UniProt 22265413
S241 Phosphorylation PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S346 O-Glycosylation GlyGen 30770249
K351 Ubiquitination PhosphoSitePlus
S359 O-Glycosylation GlyGen 30770249
S359 Phosphorylation PhosphoSitePlus
S360 O-Glycosylation GlyGen 30770249
K363 Ubiquitination UniProt 29883609
S372 Phosphorylation PhosphoSitePlus
T401 O-Glycosylation GlyGen 30770249
S402 O-Glycosylation GlyGen 30770249
T403 O-Glycosylation GlyGen 30770249
S410 O-Glycosylation GlyGen 30770249
S410 Phosphorylation PhosphoSitePlus
T412 O-Glycosylation GlyGen 30770249
T412 Phosphorylation PhosphoSitePlus
S413 O-Glycosylation GlyGen 30770249
T414 O-Glycosylation GlyGen 30770249
T416 O-Glycosylation GlyGen 30770249
S418 O-Glycosylation GlyGen 30770249
T467 O-Glycosylation GlyGen 30770249
R486 Methylation PhosphoSitePlus
S496 O-Glycosylation GlyGen 30770249
K501 Ubiquitination PhosphoSitePlus
K518 Ubiquitination PhosphoSitePlus


Q9Y572 (RIPK3) as PTM Enzyme



Substrate Site Score Source PMID
Q8NB16 (MLKL) T357 PhosphoSitePlus 22265413
Q8NB16 (MLKL) S358 PhosphoSitePlus 22265413
Q9UER7 (DAXX) S668 PhosphoSitePlus 23260419
Q9Y572 (RIPK3) S199 UniProt 11734559
Q9Y572 (RIPK3) S227 UniProt 22265413


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049047 (hRIPK3/Phos:1) pS199,pS227 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13546 (RIPK1) S166 Q9Y572 (RIPK3) unknown eFIP 28842570
Phosphorylation Q9Y572 (RIPK3) S227 Q8NB16 (MLKL) unknown eFIP 23612963
Phosphorylation Q9Y572 (RIPK3) S227 Q8NB16 (MLKL) unknown eFIP 26866270


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K5 Q5 Biomuta DOID:2021 / placenta cancer [ cosmic ]
K55 T55 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S199 P199 Biomuta [ cosmic ]
T300 M300 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S320 P320 Biomuta DOID:1324 / lung cancer [ cosmic ]
S359 I359 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S360 Y360 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T403 A403 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S418 R418 Biomuta DOID:1612 / breast cancer [ cosmic ]
R486 K486 Biomuta DOID:4159 / skin cancer [ cosmic ]