Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y572 / RIPK3_HUMAN
Protein Name Receptor-interacting serine/threonine-protein kinase 3
Gene Name Name: RIPK3
Synonyms:RIP3;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y572
DAG View
PRO Name receptor-interacting serine/threonine-protein kinase 3 (human)
Definition A receptor-interacting serine/threonine-protein kinase 3 that is encoded in the genome of human.
Short Label hRIPK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y572 (RIPK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29883609
S199 Phosphorylation Q9Y572 (RIPK3) PRO   UniProt 11734559, 19524512
T224 Phosphorylation PhosphoSitePlus
S227 Phosphorylation Q9Y572 (RIPK3) PRO   PhosphoSitePlus   RLIMS-P   UniProt 29883609, 30237400, 33369872, ...22265413, 28454582, 31932442
S241 Phosphorylation PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
K363 Ubiquitination UniProt 29883609
S372 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
T467 O-Glycosylation GlyGen 30770249
R486 Methylation PhosphoSitePlus


Q9Y572 (RIPK3) as PTM Enzyme



Substrate Site Score Source PMID
Q8NB16 (MLKL) T357 PhosphoSitePlus 22265413
Q8NB16 (MLKL) S358 PhosphoSitePlus 22265413
Q9UER7 (DAXX) S668 PhosphoSitePlus 23260419
Q9Y572 (RIPK3) S199 UniProt 11734559
Q9Y572 (RIPK3) S227 UniProt 22265413


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049047 (hRIPK3/Phos:1) pS199,pS227 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13546 (RIPK1) S166 Q9Y572 (RIPK3) unknown eFIP 28842570
Phosphorylation Q9Y572 (RIPK3) S227 Q8NB16 (MLKL) unknown eFIP 23612963
Phosphorylation Q9Y572 (RIPK3) S227 Q8NB16 (MLKL) unknown eFIP 26866270


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K55 T55 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S410 R410 Biomuta DOID:3571 / liver cancer [ icgc ]