iPTMnet Report for Q9Y572 (RIPK3)
Protein Information
| UniProt AC / UniProt ID | Q9Y572 / RIPK3_HUMAN |
| Protein Name | Receptor-interacting serine/threonine-protein kinase 3 |
| Gene Name | Name: RIPK3 Synonyms:RIP3; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9Y572 |
| PRO Name | receptor-interacting serine/threonine-protein kinase 3 (human) |
| Definition | A receptor-interacting serine/threonine-protein kinase 3 that is encoded in the genome of human. |
| Short Label | hRIPK3 |
| Category | organism-gene |
DAG ViewQ9Y572 (RIPK3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K5 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K42 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K55 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S164 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T165 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T182 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P UniProt | 29883609 | ||
| S199 | Phosphorylation | Q9Y572 (RIPK3) | score4 | PRO UniProt | 11734559, 19524512 | |
| T224 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S227 | Phosphorylation | Q9Y572 (RIPK3) | score4 | PRO PhosphoSitePlus RLIMS-P UniProt | 29883609, 30237400, 36342164, ... | |
| S241 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T252 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S299 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T300 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S316 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S320 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T325 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S339 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S346 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| K351 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S359 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| S359 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S360 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| K363 | Ubiquitination | score2 | UniProt | 29883609 | ||
| S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T401 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| S402 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| T403 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| S410 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| S410 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T412 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| T412 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S413 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| T414 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| T416 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| S418 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| T467 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| R486 | Methylation | score1 | PhosphoSitePlus | |||
| S496 | O-Glycosylation | score2 | GlyGen | 30770249 | ||
| K501 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K518 | Ubiquitination | score1 | PhosphoSitePlus |
Q9Y572 (RIPK3) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| Q8NB16 (MLKL) | T357 | score2 | PhosphoSitePlus | 22265413 | |
| Q8NB16 (MLKL) | S358 | score2 | PhosphoSitePlus | 22265413 | |
| Q9UER7 (DAXX) | S668 | score2 | PhosphoSitePlus | 23260419 | |
| Q9Y572 (RIPK3) | S199 | score2 | UniProt | 11734559 | |
| Q9Y572 (RIPK3) | S227 | score2 | UniProt | 22265413 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000049047 (hRIPK3/Phos:1) | pS199,pS227 | PRO |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q13546 (RIPK1) | S166 | Q9Y572 (RIPK3) | unknown | eFIP | 28842570 | |
| Phosphorylation | Q9Y572 (RIPK3) | S227 | Q8NB16 (MLKL) | unknown | eFIP | 23612963 | |
| Phosphorylation | Q9Y572 (RIPK3) | S227 | Q8NB16 (MLKL) | unknown | eFIP | 26866270 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K5 | Q5 | Biomuta | DOID:2021 / placenta cancer [ cosmic ] | |
| K55 | T55 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S199 | P199 | Biomuta | [ cosmic ] | |
| T300 | M300 | Biomuta | [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
| S320 | P320 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S359 | I359 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S360 | Y360 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| T403 | A403 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S418 | R418 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| R486 | K486 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |
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