iPTMnet Report for Q9Y566 (SHANK1)
Protein Information
UniProt AC / UniProt ID | Q9Y566 / SHAN1_HUMAN |
Protein Name | SH3 and multiple ankyrin repeat domains protein 1 |
Gene Name | Name: SHANK1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9Y566 |
PRO Name | SH3 and multiple ankyrin repeat domains protein 1 (human) |
Definition | An SH3 and multiple ankyrin repeat domains protein 1 that is encoded in the genome of human. |
Short Label | hSHANK1 |
Category | organism-gene |
Q9Y566 (SHANK1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S15 | Phosphorylation | score1 | PhosphoSitePlus | |||
S17 | Phosphorylation | score1 | PhosphoSitePlus | |||
S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
S26 | Phosphorylation | score1 | PhosphoSitePlus | |||
R76 | Methylation | score1 | PhosphoSitePlus | |||
K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y161 | Phosphorylation | score1 | PhosphoSitePlus | |||
K169 | Acetylation | score1 | PhosphoSitePlus | |||
Y275 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
T287 | Phosphorylation | score1 | PhosphoSitePlus | |||
S488 | Phosphorylation | score1 | PhosphoSitePlus | |||
K510 | Acetylation | score1 | PhosphoSitePlus | |||
T531 | Phosphorylation | score1 | PhosphoSitePlus | |||
S540 | Phosphorylation | score1 | PhosphoSitePlus | |||
S543 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y551 | Phosphorylation | score1 | PhosphoSitePlus | |||
R887 | Methylation | score1 | PhosphoSitePlus | |||
S890 | Phosphorylation | score1 | PhosphoSitePlus | |||
T946 | Phosphorylation | score1 | PhosphoSitePlus | |||
S948 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1097 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1287 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1382 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1436 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1506 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1512 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1522 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1533 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1788 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
T1790 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
T1794 | O-Glycosylation | score1 | GlyGen | 28657654 | ||
S1869 | O-Glycosylation | score1 | GlyGen | 28657654 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S24 | P24 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
S26 | F26 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T287 | P287 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T531 | M531 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] | |
S543 | C543 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
R887 | Q887 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
R887 | W887 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
S890 | Y890 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S1382 | L1382 | Biomuta | DOID:2394 / ovarian cancer [ cosmic ] | |
S2007 | L2007 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |