iPTMnet Report for Q9Y566 (SHANK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y566 / SHAN1_HUMAN
Protein Name SH3 and multiple ankyrin repeat domains protein 1
Gene Name Name: SHANK1
Organism Homo sapiens (Human)

PRO ID PR:Q9Y566
DAG View
PRO Name SH3 and multiple ankyrin repeat domains protein 1 (human)
Definition An SH3 and multiple ankyrin repeat domains protein 1 that is encoded in the genome of human.
Short Label hSHANK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y566 (SHANK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
R76 Methylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
K169 Acetylation PhosphoSitePlus
Y275 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T287 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
K510 Acetylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
Y551 Phosphorylation PhosphoSitePlus
R887 Methylation PhosphoSitePlus
S890 Phosphorylation PhosphoSitePlus
T946 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
Y1097 Phosphorylation PhosphoSitePlus
S1287 Phosphorylation PhosphoSitePlus
S1382 Phosphorylation PhosphoSitePlus
S1436 Phosphorylation PhosphoSitePlus
S1506 Phosphorylation PhosphoSitePlus
S1512 Phosphorylation PhosphoSitePlus
S1522 Phosphorylation PhosphoSitePlus
S1533 Phosphorylation PhosphoSitePlus
S1788 O-Glycosylation GlyGen 28657654
T1790 O-Glycosylation GlyGen 28657654
T1794 O-Glycosylation GlyGen 28657654
S1869 O-Glycosylation GlyGen 28657654
Site PTM Type PTM Enzyme Score Source PMID
Y275 Phosphorylation HPRD 18083107
S540 Phosphorylation HPRD 19413330
S543 Phosphorylation HPRD 19413330
S2007 Phosphorylation HPRD 18767875


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 P24 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S26 F26 Biomuta DOID:4159 / skin cancer [ cosmic ]
T287 P287 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T531 M531 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S543 C543 Biomuta DOID:3571 / liver cancer [ cosmic ]
R887 Q887 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R887 W887 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S890 Y890 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1382 L1382 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S2007 L2007 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]