iPTMnet Report Q9Y463 DYRK1B

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9Y463 / DYR1B_HUMAN
Protein Name	Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Gene Name	Name: DYRK1B Synonyms:MIRK;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9Y463 DAG View
PRO Name	dual specificity tyrosine-phosphorylation-regulated kinase 1B (human)
Definition	A dual specificity tyrosine-phosphorylation-regulated kinase 1B that is encoded in the genome of human.
Short Label	hDYRK1B
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9Y463 (DYRK1B) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S49	Phosphorylation		score1	PhosphoSitePlus
	K57	Acetylation		score1	PhosphoSitePlus
	Y63	Phosphorylation		score1	PhosphoSitePlus
	Y64	Phosphorylation		score1	PhosphoSitePlus
	Y111	Phosphorylation		score1	PhosphoSitePlus
	K119	Ubiquitination		score1	PhosphoSitePlus
	K127	Ubiquitination		score1	PhosphoSitePlus
	K256	Ubiquitination		score1	PhosphoSitePlus
	Y271	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	10910078, 18220336
	Y271	Phosphorylation	Q9Y463 (DYRK1B)	score3	neXtProt phospho.ELM Signor UniProt	10910078
	Y273	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18220336, 28743892, 15144186, ...18083107, 18669648, 10910078, 26346493
	Y273	Phosphorylation	Q9Y463 (DYRK1B)	score3	neXtProt phospho.ELM Signor UniProt	10910078
	S276	Phosphorylation		score1	PhosphoSitePlus
	S421	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	26346493
	S421	Phosphorylation	P28482 (MAPK1)	score2	PhosphoSitePlus	26346493
	S421	Phosphorylation	Q9Y463 (DYRK1B)	score2	PhosphoSitePlus	26346493
	Y485	Phosphorylation		score1	PhosphoSitePlus
	S486	Phosphorylation		score1	PhosphoSitePlus
	S576	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y271	Phosphorylation		score1	HPRD	10910078
	Y271	Phosphorylation	Q9Y463 (DYRK1B)	score1	HPRD	10910078
	Y273	Phosphorylation		score2	HPRD	17016520, 19901323, 18212344, ...19664995, 15144186, 18669648, 10910078
	Y273	Phosphorylation	Q9Y463 (DYRK1B)	score2	HPRD	17016520, 19901323, 18212344, ...19664995, 15144186, 18669648, 10910078
	S421	Phosphorylation		score2	PRO	26346493

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y271	Phosphorylation		score1	HPRD	10910078
	Y273	Phosphorylation		score2	HPRD	17016520, 19901323, 18212344, ...19664995, 18669648, 10910078

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y271	Phosphorylation		score1	HPRD	10910078
	Y273	Phosphorylation		score2	HPRD	17016520, 19901323, 18212344, ...19664995, 18669648, 10910078

Q9Y463 (DYRK1B) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	O75533 (SF3B1)	T434	score3	neXtProt phospho.ELM PhosphoSitePlus	16512921
	P20823 (HNF1A)	S249	score3	neXtProt phospho.ELM PhosphoSitePlus Signor	11980910
	P24385 (CCND1)	T286	score2	RLIMS-P+	24134204
	P24385 (CCND1)	T288	score4	neXtProt PhosphoSitePlus Signor	15075324, 22711815, 17046823
	P38936 (CDKN1A)	S153	score3	neXtProt phospho.ELM PhosphoSitePlus	15851482
	P46527 (CDKN1B)	S10	score3	neXtProt	15010468, 22711815
	Q02363 (ID2)	T27	score2	PhosphoSitePlus	26735018
	Q99801 (NKX3-1)	S185	score2	RLIMS-P+	25777618
	Q9UQL6 (HDAC5)	S279	score2	neXtProt	15546868
	Q9Y463 (DYRK1B)	Y271	score3	HPRD neXtProt phospho.ELM Signor UniProt	10910078
	Q9Y463 (DYRK1B)	Y273	score4	HPRD neXtProt phospho.ELM Signor UniProt	17016520, 19901323, 18212344, ...19664995, 15144186, 18669648, 10910078
	Q9Y463 (DYRK1B)	S421	score2	PhosphoSitePlus	26346493

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000045520 (hDYRK1B/iso:1/Phos:1)	pS421		PRO	26346493

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
Y271	H271	Biomuta		DOID:1324 / lung cancer [ cosmic ]