Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y463 / DYR1B_HUMAN
Protein Name Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Gene Name Name: DYRK1B
Synonyms:MIRK;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y463
DAG View
PRO Name dual specificity tyrosine-phosphorylation-regulated kinase 1B (human)
Definition A dual specificity tyrosine-phosphorylation-regulated kinase 1B that is encoded in the genome of human.
Short Label hDYRK1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y463 (DYRK1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S49 Phosphorylation PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
Y271 Phosphorylation Q9Y463 (DYRK1B) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10910078, 18220336
Y273 Phosphorylation Q9Y463 (DYRK1B) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18220336, 28743892, 15144186, ...18083107, 18669648, 10910078, 26346493
S276 Phosphorylation PhosphoSitePlus
S421 Phosphorylation Q9Y463 (DYRK1B) , P28482 (MAPK1) PhosphoSitePlus   RLIMS-P 26346493
Y485 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y271 Phosphorylation Q9Y463 (DYRK1B) HPRD 10910078
Y273 Phosphorylation Q9Y463 (DYRK1B) HPRD 17016520, 19901323, 18212344, ...19664995, 15144186, 18669648, 10910078
S421 Phosphorylation PRO 26346493
Site PTM Type PTM Enzyme Score Source PMID
Y271 Phosphorylation HPRD 10910078
Y273 Phosphorylation HPRD 17016520, 19901323, 18212344, ...19664995, 18669648, 10910078
Site PTM Type PTM Enzyme Score Source PMID
Y271 Phosphorylation HPRD 10910078
Y273 Phosphorylation HPRD 17016520, 19901323, 18212344, ...19664995, 18669648, 10910078


Q9Y463 (DYRK1B) as PTM Enzyme



Substrate Site Score Source PMID
O75533 (SF3B1) T434 neXtProt   phospho.ELM   PhosphoSitePlus 16512921
P20823 (HNF1A) S249 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11980910
P24385 (CCND1) T286 RLIMS-P+ 24134204
P24385 (CCND1) T288 neXtProt   PhosphoSitePlus   Signor 15075324, 22711815, 17046823
P38936 (CDKN1A) S153 neXtProt   phospho.ELM   PhosphoSitePlus 15851482
P46527 (CDKN1B) S10 neXtProt 15010468, 22711815
Q02363 (ID2) T27 PhosphoSitePlus 26735018
Q99801 (NKX3-1) S185 RLIMS-P+ 25777618
Q9UQL6 (HDAC5) S279 neXtProt 15546868
Q9Y463 (DYRK1B) Y271 HPRD   neXtProt   phospho.ELM   Signor   UniProt 10910078
Q9Y463 (DYRK1B) Y273 HPRD   neXtProt   phospho.ELM   Signor   UniProt 17016520, 19901323, 18212344, ...19664995, 15144186, 18669648, 10910078
Q9Y463 (DYRK1B) S421 PhosphoSitePlus 26346493


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045520 (hDYRK1B/iso:1/Phos:1) pS421 PRO 26346493


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K127 N127 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y271 H271 Biomuta DOID:1324 / lung cancer [ cosmic ]
S486 R486 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S486 I486 Biomuta DOID:363 / uterine cancer [ tcga ]