iPTMnet Report for Q9Y2X0 (MED16)
Protein Information
UniProt AC / UniProt ID | Q9Y2X0 / MED16_HUMAN |
Protein Name | Mediator of RNA polymerase II transcription subunit 16 |
Gene Name | Name: MED16 Synonyms:DRIP92; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9Y2X0 |
PRO Name | mediator of RNA polymerase II transcription subunit 16 (human) |
Definition | A mediator of RNA polymerase II transcription subunit 16 that is encoded in the genome of human. |
Short Label | hMED16 |
Category | organism-gene |
Q9Y2X0 (MED16) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
T48 | Phosphorylation | score1 | PhosphoSitePlus | |||
S53 | O-Glycosylation | score1 | GlyGen | 30379171, 34019948 | ||
C86 | Methylation | score1 | IEDB | 31844290 | ||
K149 | Ubiquitination | score1 | PhosphoSitePlus | |||
K158 | Ubiquitination | score1 | PhosphoSitePlus | |||
K252 | Ubiquitination | score1 | PhosphoSitePlus | |||
T257 | Phosphorylation | score1 | PhosphoSitePlus | |||
K276 | Ubiquitination | score1 | PhosphoSitePlus | |||
K284 | Ubiquitination | score1 | PhosphoSitePlus | |||
C308 | Methylation | score1 | IEDB | 31844290 | ||
K313 | Ubiquitination | score1 | PhosphoSitePlus | |||
S326 | Phosphorylation | score1 | PhosphoSitePlus | |||
K332 | Ubiquitination | score1 | PhosphoSitePlus | |||
K338 | Ubiquitination | score1 | PhosphoSitePlus | |||
K358 | Ubiquitination | score1 | PhosphoSitePlus | |||
T364 | Phosphorylation | score1 | PhosphoSitePlus | |||
K530 | Ubiquitination | score1 | PhosphoSitePlus | |||
K535 | Ubiquitination | score1 | PhosphoSitePlus | |||
C539 | Methylation | score1 | IEDB | 31844290 | ||
C545 | Methylation | score1 | IEDB | 31844290 | ||
Y547 | Phosphorylation | score1 | PhosphoSitePlus | |||
T549 | Phosphorylation | score1 | PhosphoSitePlus | |||
T571 | Phosphorylation | score1 | PhosphoSitePlus | |||
K574 | Ubiquitination | score1 | PhosphoSitePlus | |||
C584 | Methylation | score1 | IEDB | 31844290 | ||
K586 | Ubiquitination | score1 | PhosphoSitePlus | |||
T588 | Phosphorylation | score1 | PhosphoSitePlus | |||
K594 | Ubiquitination | score1 | PhosphoSitePlus | |||
C672 | Methylation | score1 | IEDB | 31844290 | ||
T682 | Phosphorylation | score1 | PhosphoSitePlus | |||
S685 | Phosphorylation | score1 | PhosphoSitePlus | |||
S687 | Phosphorylation | score1 | PhosphoSitePlus | |||
T694 | Phosphorylation | score1 | PhosphoSitePlus | |||
K695 | Ubiquitination | score1 | PhosphoSitePlus | |||
K745 | Ubiquitination | score1 | PhosphoSitePlus | |||
T757 | Phosphorylation | score1 | PhosphoSitePlus | |||
K778 | Ubiquitination | score1 | PhosphoSitePlus | |||
K796 | Ubiquitination | score1 | PhosphoSitePlus | |||
K808 | Methylation | score1 | PhosphoSitePlus | |||
K808 | Ubiquitination | score1 | PhosphoSitePlus | |||
K817 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S53 | G53 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
C584 | Y584 | Biomuta | DOID:11615 / penile cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] | |
K586 | E586 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
T588 | I588 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K594 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S687 | Y687 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
K695 | T695 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
K778 | E778 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] |