Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2X0 / MED16_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 16
Gene Name Name: MED16
Synonyms:DRIP92;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2X0
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 16 (human)
Definition A mediator of RNA polymerase II transcription subunit 16 that is encoded in the genome of human.
Short Label hMED16
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2X0 (MED16) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K26 Ubiquitination PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
T364 Phosphorylation PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
Y547 Phosphorylation PhosphoSitePlus
T549 Phosphorylation PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
T682 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
T694 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
K745 Ubiquitination PhosphoSitePlus
T757 Phosphorylation PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K808 Methylation PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T257 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T364 N364 Biomuta DOID:3571 / liver cancer [ icgc ]
K586 E586 Biomuta DOID:363 / uterine cancer [ tcga ]
K778 E778 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]