Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2M0 / FAN1_HUMAN
Protein Name Fanconi-associated nuclease 1
Gene Name Name: FAN1
Synonyms:KIAA1018;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2M0
DAG View
PRO Name Fanconi-associated nuclease 1 (human)
Definition A Fanconi-associated nuclease 1 that is encoded in the genome of human.
Short Label hFAN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2M0 (FAN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
T110 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
Y163 Phosphorylation PhosphoSitePlus
S169 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus   UniProt 23186163
S197 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K977 Ubiquitination PhosphoSitePlus
K986 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y128 H128 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S160 P160 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S160 C160 Biomuta DOID:1324 / lung cancer [ cosmic ]
S692 R692 Biomuta DOID:4362 / cervical cancer [ tcga ]