iPTMnet Report for Q9Y2J4 (AMOTL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y2J4 / AMOL2_HUMAN
Protein Name Angiomotin-like protein 2
Gene Name Name: AMOTL2
Synonyms:KIAA0989;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y2J4
DAG View
PRO Name angiomotin-like protein 2 (human)
Definition An angiomotin-like protein 2 that is encoded in the genome of human.
Short Label hAMOTL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y2J4 (AMOTL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation PhosphoSitePlus
Y22 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
Y107 Phosphorylation P11362 (FGFR1) PhosphoSitePlus   Signor 21937427
S157 Phosphorylation PhosphoSitePlus
S159 Phosphorylation Q9NRM7 (LATS2) PhosphoSitePlus 24225952
S166 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
R197 Methylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
T375 O-Glycosylation GlyGen 30379171, 29237092
K408 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
K519 Sumoylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
Y573 Phosphorylation PhosphoSitePlus
T596 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
S759 Phosphorylation P42345 (MTOR) PhosphoSitePlus   UniProt 25998128, 24275569
S762 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation HPRD 20068231
S183 Phosphorylation HPRD 19651622
S236 Phosphorylation HPRD 19691289
S534 Phosphorylation HPRD 20068231
S540 Phosphorylation HPRD 19664994, 19691289, 20068231
T597 Phosphorylation HPRD 20068231
S606 Phosphorylation HPRD 20068231
S661 Phosphorylation HPRD 19691289
S760 Phosphorylation HPRD 19007248, 19691289


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S157 L157 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S176 G176 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S236 C236 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K422 R422 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S540 F540 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S602 Y602 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S602 F602 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S606 L606 Biomuta DOID:4159 / skin cancer [ cosmic ]
S667 L667 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc, cosmic ]