Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UQL6 / HDAC5_HUMAN
Protein Name Histone deacetylase 5
Gene Name Name: HDAC5
Synonyms:KIAA0600;
Organism Homo sapiens (Human)

PRO ID PR:Q9UQL6
DAG View
PRO Name histone deacetylase 5 (human)
Definition A histone deacetylase 5 that is encoded in the genome of human.
Short Label hHDAC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UQL6 (HDAC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
K35 Sumoylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
T70 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S259 Phosphorylation O43318 (MAP3K7) , Q05655 (PRKCD) , Q13555 (CAMK2G) , Q7KZI7 (MARK2) , Q9UQM7 (CAMK2A) , Q16566 (CAMK4) , P57059 (SIK1) , Q15139 (PRKD1) , Q13131 (PRKAA1) , Q14012 (CAMK1) , P54646 (PRKAA2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24207022, 17468767, 11081517, ...21146494, 29339432, 21892142, 16584705, 16980613, 18184930, 29520168, 12058061, 11114197, 24841198, 26061431, 18332134
S278 Phosphorylation Q96GD4 (AURKB) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 22865920, 21081666
S279 Phosphorylation Q9Y463 (DYRK1B) , P17612 (PRKACA) , Q00535 (CDK5) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 23161540, 21081666, 27759007, ...20716686, 22865920, 15546868, 22243750, 28343149
T288 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
T292 Phosphorylation Q16512 (PKN1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 20188095
S368 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
T496 Phosphorylation PhosphoSitePlus
S498 Phosphorylation P54646 (PRKAA2) , Q14012 (CAMK1) , Q16566 (CAMK4) , Q13555 (CAMK2G) , Q13557 (CAMK2D) , Q9UQM7 (CAMK2A) , P57059 (SIK1) , Q15139 (PRKD1) , O94806 (PRKD3) , Q13131 (PRKAA1) , Q9BZL6 (PRKD2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24207022, 17468767, 11081517, ...21146494, 29339432, 12058061, 22360269, 16584705, 21892142, 21998325, 18184930, 26061431, 22865920, 27667720, 18292392, 11114197, 29520168, 18332134
S504 Phosphorylation PhosphoSitePlus
K533 Acetylation PhosphoSitePlus   UniProt 19608861
K533 Sumoylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
K605 Sumoylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24920159, 23186163
S661 Phosphorylation PhosphoSitePlus   UniProt 23186163
S671 Phosphorylation PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus   RLIMS-P 24920159, 21081666
Y776 Phosphorylation PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
S1071 Phosphorylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24920159, 23186163, 21081666
Site PTM Type PTM Enzyme Score Source PMID
S259 Phosphorylation Q14012 (CAMK1) , PR:Q14012 (hCAMK1) , Q15139 (PRKD1) HPRD   PRO 11114197, 11081517, 15367659, ...11509672
S498 Phosphorylation Q15139 (PRKD1) , Q14012 (CAMK1) , PR:Q14012 (hCAMK1) HPRD   PRO 11114197, 11081517, 15367659, ...11509672
Site PTM Type PTM Enzyme Score Source PMID
S260 Phosphorylation Q15139 (PRKD1) , Q14012 (CAMK1) HPRD 11114197, 11081517, 15367659
S499 Phosphorylation Q15139 (PRKD1) , Q14012 (CAMK1) HPRD 11114197, 11081517, 15367659


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000029006 (hHDAC5/iso:1/Phos:1) pS259,pS498 PR:Q14012 (hCAMK1) PRO 11114197, 11509672


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000029006 (hHDAC5/iso:1/Phos:1) Interaction PRO 11114197


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T234 M234 Biomuta DOID:5041 / esophageal cancer [ tcga ]
T292 I292 Biomuta DOID:4362 / cervical cancer [ tcga ]
T547 N547 Biomuta DOID:3571 / liver cancer [ icgc ]
Y776 C776 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S799 R799 Biomuta DOID:363 / uterine cancer [ tcga ]