iPTMnet Report for Q9UMX1 (SUFU)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UMX1 / SUFU_HUMAN
Protein Name Suppressor of fused homolog
Gene Name Name: SUFU
ORFNames:UNQ650/PRO1280;
Organism Homo sapiens (Human)

PRO ID PR:Q9UMX1
DAG View
PRO Name suppressor of fused homolog (human)
Definition A suppressor of fused homolog that is encoded in the genome of human.
Short Label hSUFU
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UMX1 (SUFU) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus   UniProt 27234298
S290 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus   UniProt 23186163
K303 Acetylation PhosphoSitePlus   UniProt 19608861
K303 Ubiquitination PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S342 Phosphorylation P17612 (PRKACA) , P49841 (GSK3B) PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 27234298, 21317289, ...32826873, 23337587
K344 Ubiquitination PhosphoSitePlus
S346 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   Signor   UniProt 27234298, 23337587, 23186163, ...21317289
S349 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27234298
T353 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27234298
K457 Ubiquitination PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
S481 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Site PTM Type PTM Enzyme Score Source PMID
S481 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9UMX1 (SUFU) S352 Q9UF56 (FBXL17) decreased_association eFIP 27234298


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T13 P13 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K257 * Biomuta DOID:5158 / pleural cancer [ cosmic ]
S301 F301 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K303 T303 Biomuta DOID:1324 / lung cancer [ cosmic ]
S342 N342 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S352 F352 Biomuta DOID:4159 / skin cancer [ cosmic ]
T353 M353 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
K470 N470 Biomuta DOID:363 / uterine cancer [ icgc ]