iPTMnet Report for Q9UMX1 (SUFU)
Protein Information
| UniProt AC / UniProt ID | Q9UMX1 / SUFU_HUMAN |
| Protein Name | Suppressor of fused homolog |
| Gene Name | Name: SUFU ORFNames:UNQ650/PRO1280; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9UMX1 |
| PRO Name | suppressor of fused homolog (human) |
| Definition | A suppressor of fused homolog that is encoded in the genome of human. |
| Short Label | hSUFU |
| Category | organism-gene |
DAG ViewQ9UMX1 (SUFU) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T13 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T21 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K257 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 27234298 | ||
| S290 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S301 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K303 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K303 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T305 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K321 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S342 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P Signor UniProt | 23186163, 27234298, 21317289, ... | ||
| S342 | Phosphorylation | P17612 (PRKACA) | score2 | Signor | 21317289, 23337587 | |
| S342 | Phosphorylation | P49841 (GSK3B) | score2 | PhosphoSitePlus | 21317289 | |
| K344 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S346 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P Signor UniProt | 27234298, 23337587, 23186163, ... | ||
| S346 | Phosphorylation | P17612 (PRKACA) | score4 | PhosphoSitePlus Signor | 21317289, 23337587 | |
| S349 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S352 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P UniProt | 27234298 | ||
| T353 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P UniProt | 27234298 | ||
| K457 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K470 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S481 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9UMX1 (SUFU) | S352 | Q9UF56 (FBXL17) | decreased_association | eFIP | 27234298 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T13 | P13 | Biomuta | DOID:1319 / brain cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K257 | * | Biomuta | DOID:5158 / pleural cancer [ cosmic ] | |
| S301 | F301 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| K303 | T303 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S342 | N342 | Biomuta | DOID:2531 / hematologic cancer [ cosmic, icgc ] | |
| S352 | F352 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T353 | M353 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] | |
| K470 | N470 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
