iPTMnet Report Q9ULV8 CBLC

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9ULV8 / CBLC_HUMAN
Protein Name	E3 ubiquitin-protein ligase CBL-C
Gene Name	Name: CBLC Synonyms:CBL3,RNF57;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9ULV8 DAG View
PRO Name	E3 ubiquitin-protein ligase CBL-C (human)
Definition	An E3 ubiquitin-protein ligase CBL-C that is encoded in the genome of human.
Short Label	hCBLC
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9ULV8 (CBLC) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S40	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	15302935
	S43	Phosphorylation		score1	PhosphoSitePlus
	S61	Phosphorylation		score1	PhosphoSitePlus
	S105	Phosphorylation		score1	PhosphoSitePlus
	T223	Phosphorylation		score1	PhosphoSitePlus
	Y309	Phosphorylation		score1	PhosphoSitePlus
	K313	Ubiquitination		score1	PhosphoSitePlus
	Y341	Phosphorylation	P12931 (SRC)	score4	PhosphoSitePlus RLIMS-P Signor UniProt	23145173, 20525694, 24425877
	Y402	Phosphorylation		score1	PhosphoSitePlus
	S461	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S40	Phosphorylation		score0	HPRD	15302935
	S61	Phosphorylation		score0	HPRD	19413330

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S43	L43	Biomuta		DOID:4159 / skin cancer [ cosmic ]
Y309	S309	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]
Y341	C341	Biomuta		DOID:1324 / lung cancer [ cosmic ]