iPTMnet Report for Q9UBS0 (RPS6KB2)
Protein Information
| UniProt AC / UniProt ID | Q9UBS0 / KS6B2_HUMAN |
| Protein Name | Ribosomal protein S6 kinase beta-2 |
| Gene Name | Name: RPS6KB2 Synonyms:STK14B; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9UBS0 |
| PRO Name | ribosomal protein S6 kinase beta-2 (human) |
| Definition | A ribosomal protein S6 kinase beta-2 that is encoded in the genome of human. |
| Short Label | hRPS6KB2 |
| Category | organism-gene |
DAG ViewQ9UBS0 (RPS6KB2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S15 | Phosphorylation | score2 | phospho.ELM UniProt | 17081983 | ||
| S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y45 | Phosphorylation | score3 | PhosphoSitePlus Signor | 16640565 | ||
| Y45 | Phosphorylation | P12931 (SRC) | score3 | PhosphoSitePlus Signor | 16640565 | |
| K75 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K80 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K94 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y96 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K111 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y136 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K196 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S219 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T226 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T228 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P Signor | 15209375, 12713446, 9445476 | ||
| T228 | Phosphorylation | O15530 (PDPK1) | score2 | Signor | 15209375, 9445476 | |
| S254 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S266 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T270 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K276 | Acetylation | score1 | PhosphoSitePlus | |||
| K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K285 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S356 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17525332 | ||
| T388 | Phosphorylation | score2 | phospho.ELM | 14560963 | ||
| T388 | Phosphorylation | P42345 (MTOR) | score2 | phospho.ELM | 14560963 | |
| K407 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S410 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S416 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S417 | Phosphorylation | score2 | IEDB PhosphoSitePlus UniProt | 27920218, 23186163 | ||
| S423 | Phosphorylation | score2 | IEDB PhosphoSitePlus UniProt | 27920218, 23186163 | ||
| S473 | Phosphorylation | score3 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 12529391 | ||
| S473 | Phosphorylation | P05129 (PRKCG) | score3 | PhosphoSitePlus Signor | 12529391 | |
| S473 | Phosphorylation | P05771 (PRKCB) | score3 | neXtProt PhosphoSitePlus Signor | 12529391 | |
| S473 | Phosphorylation | P17252 (PRKCA) | score3 | PhosphoSitePlus Signor | 12529391 | |
| S473 | Phosphorylation | P41743 (PRKCI) | score2 | PhosphoSitePlus | 12529391 | |
| S473 | Phosphorylation | Q02156 (PRKCE) | score3 | PhosphoSitePlus Signor | 12529391 | |
| S473 | Phosphorylation | Q05513 (PRKCZ) | score2 | PhosphoSitePlus | 12529391 | |
| S473 | Phosphorylation | Q05655 (PRKCD) | score3 | PhosphoSitePlus Signor | 12529391 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S15 | Phosphorylation | score2 | HPRD PRO | 17081983 | ||
| T228 | Phosphorylation | score1 | HPRD | 11733037 | ||
| T228 | Phosphorylation | O15530 (PDPK1) | score1 | HPRD | 11733037 | |
| T228 | Phosphorylation | P42345 (MTOR) | score1 | HPRD | 11733037 | |
| S356 | Phosphorylation | score2 | HPRD PRO | 17525332 | ||
| S370 | Phosphorylation | score1 | HPRD | 11733037 | ||
| S370 | Phosphorylation | O15530 (PDPK1) | score1 | HPRD | 11733037 | |
| S370 | Phosphorylation | P42345 (MTOR) | score1 | HPRD | 11733037 | |
| T388 | Phosphorylation | score1 | HPRD | 11733037 | ||
| T388 | Phosphorylation | O15530 (PDPK1) | score1 | HPRD | 11733037 | |
| T388 | Phosphorylation | P42345 (MTOR) | score1 | HPRD | 11733037 |
Q9UBS0 (RPS6KB2) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| O00418 (EEF2K) | S366 | score3 | neXtProt PhosphoSitePlus | 11500364 | |
| P04792 (HSPB1) | S78 | score2 | PhosphoSitePlus | 1730670 | |
| P04792 (HSPB1) | S82 | score2 | PhosphoSitePlus | 1730670 | |
| P05783 (KRT18) | S53 | score2 | PhosphoSitePlus | 7523419 | |
| P09651 (HNRNPA1) | S4 | score2 | RLIMS-P+ | 25324306 | |
| P09651 (HNRNPA1) | S6 | score2 | RLIMS-P+ | 25324306 | |
| P49841 (GSK3B) | S9 | score2 | PhosphoSitePlus | 21422248 | |
| Q05195 (MXD1) | S145 | score1 | Signor | 18451027 | |
| Q53EL6 (PDCD4) | S67 | score2 | neXtProt | 22431522 | |
| Q6R327 (RICTOR) | T1135 | score2 | PhosphoSitePlus | 19935711 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000026339 (hRPS6KB2/iso:1/Phos:1) | pS15,pS356 | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S15 | G15 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K86 | N86 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| K94 | R94 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| K111 | N111 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Y136 | C136 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S254 | I254 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S266 | L266 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K280 | N280 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S356 | G356 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S410 | L410 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] |
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