Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9UBS0 / KS6B2_HUMAN
Protein Name Ribosomal protein S6 kinase beta-2
Gene Name Name: RPS6KB2
Organism Homo sapiens (Human)

DAG View
PRO Name ribosomal protein S6 kinase beta-2 (human)
Definition A ribosomal protein S6 kinase beta-2 that is encoded in the genome of human.
Short Label hRPS6KB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9UBS0 (RPS6KB2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation phospho.ELM   UniProt 17081983
S24 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 16640565
K75 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
T228 Phosphorylation O15530 (PDPK1) PhosphoSitePlus   RLIMS-P   Signor 15209375, 12713446, 9445476
S254 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
S356 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T388 Phosphorylation P42345 (MTOR) phospho.ELM 14560963
K407 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus   UniProt 23186163
S423 Phosphorylation PhosphoSitePlus   UniProt 23186163
S473 Phosphorylation P05771 (PRKCB) , Q05513 (PRKCZ) , P41743 (PRKCI) , Q05655 (PRKCD) , P05129 (PRKCG) , Q02156 (PRKCE) , P17252 (PRKCA) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12529391
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD   PRO 17081983
T228 Phosphorylation O15530 (PDPK1) , P42345 (MTOR) HPRD 11733037
S356 Phosphorylation HPRD   PRO 17525332
S370 Phosphorylation O15530 (PDPK1) , P42345 (MTOR) HPRD 11733037
T388 Phosphorylation P42345 (MTOR) , O15530 (PDPK1) HPRD 11733037

Q9UBS0 (RPS6KB2) as PTM Enzyme

Substrate Site Score Source PMID
O00418 (EEF2K) S366 neXtProt   PhosphoSitePlus 11500364
P04792 (HSPB1) S78 PhosphoSitePlus 1730670
P04792 (HSPB1) S82 PhosphoSitePlus 1730670
P05783 (KRT18) S53 PhosphoSitePlus 7523419
P09651 (HNRNPA1) S4 RLIMS-P+ 25324306
P09651 (HNRNPA1) S6 RLIMS-P+ 25324306
P49841 (GSK3B) S9 PhosphoSitePlus 21422248
Q05195 (MXD1) S145 Signor 18451027
Q53EL6 (PDCD4) S67 neXtProt 22431522
Q6R327 (RICTOR) T1135 PhosphoSitePlus 19935711


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000026339 (hRPS6KB2/iso:1/Phos:1) pS15,pS356 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y136 C136 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S254 I254 Biomuta DOID:363 / uterine cancer [ tcga ]
K280 N280 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S356 G356 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S410 L410 Biomuta DOID:4362 / cervical cancer [ tcga ]