iPTMnet Report for Q9UBI9 (HECA)
Protein Information
UniProt AC / UniProt ID | Q9UBI9 / HDC_HUMAN |
Protein Name | Headcase protein homolog |
Gene Name | Name: HECA Synonyms:HDC; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9UBI9 |
PRO Name | headcase protein homolog (human) |
Definition | A headcase protein that is encoded in the genome of human. |
Short Label | hHECA |
Category | organism-gene |
Q9UBI9 (HECA) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K110 | Ubiquitination | score1 | PhosphoSitePlus | |||
K195 | Methylation | score1 | PhosphoSitePlus | |||
K195 | Ubiquitination | score1 | PhosphoSitePlus | |||
S244 | Phosphorylation | score1 | PhosphoSitePlus | |||
S250 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y260 | Phosphorylation | score1 | PhosphoSitePlus | |||
S264 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648, 19690332 | ||
S268 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 18669648, 19690332 | ||
S272 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 18669648 | ||
T275 | Phosphorylation | score0 | HPRD | 17081983 | ||
Y277 | Phosphorylation | score0 | HPRD | 17081983 | ||
S278 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 17081983 | ||
R289 | Methylation | score1 | PhosphoSitePlus | |||
Y324 | Phosphorylation | score1 | PhosphoSitePlus | |||
S325 | Phosphorylation | score1 | PhosphoSitePlus | |||
R333 | Methylation | score1 | PhosphoSitePlus | |||
S389 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
S391 | O-Glycosylation | score1 | GlyGen | 29351928 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S264 | F264 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S278 | P278 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
R289 | C289 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ icgc ] | |
R289 | H289 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R333 | S333 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] |