iPTMnet Report for Q9UBI9 (HECA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UBI9 / HDC_HUMAN
Protein Name Headcase protein homolog
Gene Name Name: HECA
Synonyms:HDC;
Organism Homo sapiens (Human)

PRO ID PR:Q9UBI9
DAG View
PRO Name headcase protein homolog (human)
Definition A headcase protein that is encoded in the genome of human.
Short Label hHECA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UBI9 (HECA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K110 Ubiquitination PhosphoSitePlus
K195 Methylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
S264 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S268 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S272 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T275 Phosphorylation HPRD 17081983
Y277 Phosphorylation HPRD 17081983
S278 Phosphorylation HPRD   PhosphoSitePlus 17081983
R289 Methylation PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
R333 Methylation PhosphoSitePlus
S389 O-Glycosylation GlyGen 29351928
S391 O-Glycosylation GlyGen 29351928


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S264 F264 Biomuta DOID:4159 / skin cancer [ cosmic ]
S278 P278 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R289 C289 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ icgc ]
R289 H289 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R333 S333 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]