iPTMnet Report for Q9NZJ5 (EIF2AK3)
Protein Information
UniProt AC / UniProt ID | Q9NZJ5 / E2AK3_HUMAN |
Protein Name | Eukaryotic translation initiation factor 2-alpha kinase 3 precursor |
Gene Name | Name: EIF2AK3 Synonyms:PEK,PERK; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9NZJ5 |
PRO Name | eukaryotic translation initiation factor 2-alpha kinase 3 (human) |
Definition | A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of human. |
Short Label | hEIF2AK3 |
Category | organism-gene |
Q9NZJ5 (EIF2AK3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T54 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
S55 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
T57 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
T177 | Phosphorylation | score1 | PhosphoSitePlus | |||
N254 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
N258 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
Y268 | Phosphorylation | score1 | PhosphoSitePlus | |||
T441 | Phosphorylation | score1 | PhosphoSitePlus | |||
S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
K452 | Ubiquitination | score1 | PhosphoSitePlus | |||
S455 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y464 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y474 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y480 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y481 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y484 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y485 | Phosphorylation | score1 | PhosphoSitePlus | |||
S555 | Phosphorylation | score1 | PhosphoSitePlus | |||
T557 | Phosphorylation | score1 | PhosphoSitePlus | |||
T561 | Phosphorylation | score1 | PhosphoSitePlus | |||
S567 | Phosphorylation | score1 | PhosphoSitePlus | |||
K581 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y585 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y619 | Phosphorylation | Q9NZJ5 (EIF2AK3) | score4 | PhosphoSitePlus RLIMS-P Signor UniProt | 17998206, 22169477 | |
K622 | Ubiquitination | score1 | PhosphoSitePlus | |||
K669 | Ubiquitination | score1 | PhosphoSitePlus | |||
S688 | Phosphorylation | score1 | PhosphoSitePlus | |||
S694 | Phosphorylation | score1 | PhosphoSitePlus | |||
T705 | Phosphorylation | score1 | PhosphoSitePlus | |||
S715 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 18691976, 20068231 | ||
S719 | Phosphorylation | score1 | PhosphoSitePlus | |||
T802 | Phosphorylation | P31751 (AKT2) , P31749 (AKT1) | score3 | neXtProt PhosphoSitePlus | 21954288 | |
S803 | Phosphorylation | score1 | PhosphoSitePlus | |||
S804 | Phosphorylation | score1 | PhosphoSitePlus | |||
S811 | Phosphorylation | score1 | PhosphoSitePlus | |||
S844 | Phosphorylation | score1 | PhosphoSitePlus | |||
S845 | Phosphorylation | score1 | PhosphoSitePlus | |||
S854 | Phosphorylation | score1 | PhosphoSitePlus | |||
S856 | Phosphorylation | score1 | PhosphoSitePlus | |||
T861 | Phosphorylation | score0 | HPRD | 20068231 | ||
T862 | Phosphorylation | score0 | HPRD | 20068231 | ||
S879 | Phosphorylation | score1 | PhosphoSitePlus | |||
T982 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1094 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
S1096 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1109 | Phosphorylation | score1 | PhosphoSitePlus | |||
S1111 | Phosphorylation | score1 | PhosphoSitePlus |
Q9NZJ5 (EIF2AK3) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
P05198 (EIF2S1) | S49 | score2 | PhosphoSitePlus | 16289913 | |
P05198 (EIF2S1) | S52 | score4 | HPRD neXtProt phospho.ELM PhosphoSitePlus Signor | 17998206, 11907036, 8099443, ... | |
Q9NZJ5 (EIF2AK3) | Y619 | score1 | Signor | 17998206 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T54 | S54 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
N254 | D254 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
T441 | S441 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S447 | P447 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y464 | C464 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
K581 | N581 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K622 | N622 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
T705 | K705 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
S803 | F803 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S804 | Y804 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S811 | C811 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
T861 | N861 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
T861 | P861 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |