iPTMnet Report for Q9NZJ5 (EIF2AK3)
Protein Information
| UniProt AC / UniProt ID | Q9NZJ5 / E2AK3_HUMAN |
| Protein Name | Eukaryotic translation initiation factor 2-alpha kinase 3 precursor |
| Gene Name | Name: EIF2AK3 Synonyms:PEK,PERK; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9NZJ5 |
| PRO Name | eukaryotic translation initiation factor 2-alpha kinase 3 (human) |
| Definition | A eukaryotic translation initiation factor 2-alpha kinase 3 that is encoded in the genome of human. |
| Short Label | hEIF2AK3 |
| Category | organism-gene |
DAG ViewQ9NZJ5 (EIF2AK3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T54 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| S55 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| T57 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| T177 | Phosphorylation | score1 | PhosphoSitePlus | |||
| N254 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| N258 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| Y268 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T441 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K452 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S455 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y464 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y474 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y480 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y481 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y484 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y485 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S555 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T557 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T561 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S567 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K581 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y585 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y619 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P Signor UniProt | 17998206, 22169477 | ||
| Y619 | Phosphorylation | Q9NZJ5 (EIF2AK3) | score1 | Signor | 17998206 | |
| K622 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K669 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S688 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S694 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T705 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S715 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 18691976, 20068231 | ||
| S719 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T802 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 21954288 | ||
| T802 | Phosphorylation | P31749 (AKT1) | score2 | neXtProt | 21954288 | |
| T802 | Phosphorylation | P31751 (AKT2) | score2 | neXtProt | 21954288 | |
| S803 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S804 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S811 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S844 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S845 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S854 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S856 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T861 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T862 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S879 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T982 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1094 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
| S1096 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1109 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1111 | Phosphorylation | score1 | PhosphoSitePlus |
Q9NZJ5 (EIF2AK3) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P05198 (EIF2S1) | S49 | score2 | PhosphoSitePlus | 16289913 | |
| P05198 (EIF2S1) | S52 | score4 | HPRD neXtProt phospho.ELM PhosphoSitePlus Signor | 17998206, 11907036, 8099443, ... | |
| Q9NZJ5 (EIF2AK3) | Y619 | score1 | Signor | 17998206 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T54 | S54 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| N254 | D254 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| T441 | S441 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S447 | P447 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| Y464 | C464 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K581 | N581 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K622 | N622 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| T705 | K705 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| S803 | F803 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S804 | Y804 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S811 | C811 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| T861 | N861 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| T861 | P861 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |
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