Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9NVS9 / PNPO_HUMAN
Protein Name Pyridoxine-5'-phosphate oxidase
Gene Name Name: PNPO
Organism Homo sapiens (Human)

DAG View
PRO Name pyridoxine-5'-phosphate oxidase (human)
Definition A pyridoxine-5'-phosphate oxidase that is encoded in the genome of human.
Short Label hPNPO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9NVS9 (PNPO) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
C156 S-Nitrosylation dbSNO 26338901
Y157 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
R181 Methylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus   UniProt 24275569
S241 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation HPRD 17287340, 20068231
S164 Phosphorylation HPRD 20166139
S241 Phosphorylation HPRD 20166139

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S40 N40 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
C156 F156 Biomuta DOID:3571 / liver cancer [ icgc ]
Y157 H157 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S164 I164 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S165 I165 Biomuta DOID:3571 / liver cancer [ icgc ]
S165 R165 Biomuta DOID:9256 / colorectal cancer [ icgc ]