iPTMnet Report for Q9NVP1 (DDX18)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NVP1 / DDX18_HUMAN
Protein Name ATP-dependent RNA helicase DDX18
Gene Name Name: DDX18
Synonyms:cPERP-D;
Organism Homo sapiens (Human)

PRO ID PR:Q9NVP1
DAG View
PRO Name ATP-dependent RNA helicase DDX18 (human)
Definition An ATP-dependent RNA helicase DDX18 that is encoded in the genome of human.
Short Label hDDX18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NVP1 (DDX18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD   PhosphoSitePlus 20068231
K7 Acetylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
T47 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
S74 Phosphorylation HPRD   PhosphoSitePlus 18077418
K82 Acetylation PhosphoSitePlus
S86 Phosphorylation HPRD   PhosphoSitePlus 20068231
T91 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K135 Sumoylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
T225 Phosphorylation HPRD   PhosphoSitePlus 18491316
S227 Phosphorylation HPRD   PhosphoSitePlus 18491316
T230 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
T356 Phosphorylation IEDB 35494241
T360 Phosphorylation PhosphoSitePlus
T368 Phosphorylation HPRD   PhosphoSitePlus 20068231
K370 Ubiquitination PhosphoSitePlus
K380 Sumoylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
Y447 Phosphorylation PhosphoSitePlus
K458 Acetylation PhosphoSitePlus
K545 Acetylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
K571 Acetylation PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K577 Acetylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
R588 Methylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
R635 Methylation PhosphoSitePlus
Y643 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 L36 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
K135 E135 Biomuta DOID:3571 / liver cancer [ cosmic ]
T230 A230 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T319 I319 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K348 N348 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T360 A360 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T360 N360 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S434 F434 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S434 Y434 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S437 P437 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K545 Q545 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K577 M577 Biomuta DOID:1324 / lung cancer [ cosmic ]
R588 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]