iPTMnet Report for Q9NS23 (RASSF1)
Protein Information
| UniProt AC / UniProt ID | Q9NS23 / RASF1_HUMAN |
| Protein Name | Ras association domain-containing protein 1 |
| Gene Name | Name: RASSF1 Synonyms:RDA32; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9NS23 |
| PRO Name | Ras association domain-containing protein 1 (human) |
| Definition | A Ras association domain-containing protein 1 that is encoded in the genome of human. |
| Short Label | hRASSF1 |
| Category | organism-gene |
DAG ViewQ9NS23 (RASSF1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Acetylation | score1 | UniProt | 19369195 | ||
| S2 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
| R18 | Methylation | score1 | PhosphoSitePlus | |||
| K21 | Acetylation | score1 | PhosphoSitePlus | |||
| R36 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| S135 | Phosphorylation | score4 | neXtProt PhosphoSitePlus Signor | 10608806, 19962312 | ||
| S135 | Phosphorylation | Q13315 (ATM) | score4 | neXtProt PhosphoSitePlus Signor | 10608806, 19962312 | |
| K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K185 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S188 | Phosphorylation | score3 | PhosphoSitePlus Signor | 24197116 | ||
| S188 | Phosphorylation | O14757 (CHEK1) | score1 | Signor | 24197116 | |
| R198 | Methylation | score1 | PhosphoSitePlus | |||
| T206 | Phosphorylation | score3 | PhosphoSitePlus Signor | 17563743 | ||
| T206 | Phosphorylation | O14965 (AURKA) | score1 | Signor | 17563743 | |
| S207 | Phosphorylation | score4 | neXtProt PhosphoSitePlus Signor | 18071316, 19276349, 17563743 | ||
| S207 | Phosphorylation | O14965 (AURKA) | score1 | Signor | 17563743 | |
| S207 | Phosphorylation | P11802 (CDK4) | score1 | Signor | 18071316 | |
| S207 | Phosphorylation | Q96GD4 (AURKB) | score1 | Signor | 19276349 | |
| K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S222 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T224 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K236 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K245 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y259 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K262 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K281 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K326 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T38 | Phosphorylation | score2 | PhosphoSitePlus | 24197116 | ||
| T38 | Phosphorylation | O14757 (CHEK1) | score2 | PhosphoSitePlus | 24197116 | |
| T43 | Phosphorylation | score2 | PhosphoSitePlus | 24197116 | ||
| T43 | Phosphorylation | O14757 (CHEK1) | score2 | PhosphoSitePlus | 24197116 | |
| S131 | Phosphorylation | score3 | PhosphoSitePlus | 25368379, 19962312 | ||
| S131 | Phosphorylation | Q13315 (ATM) | score2 | PhosphoSitePlus | 19962312 | |
| S131 | Phosphorylation | Q13535 (ATR) | score2 | PhosphoSitePlus | 25368379 | |
| S175 | Phosphorylation | score2 | PhosphoSitePlus | 20069457 | ||
| S175 | Phosphorylation | P49841 (GSK3B) | score2 | PhosphoSitePlus | 20069457 | |
| S178 | Phosphorylation | score2 | PhosphoSitePlus | 20069457 | ||
| S178 | Phosphorylation | P49841 (GSK3B) | score2 | PhosphoSitePlus | 20069457 | |
| S179 | Phosphorylation | score2 | PhosphoSitePlus | 20069457 | ||
| S179 | Phosphorylation | P49841 (GSK3B) | score2 | PhosphoSitePlus | 20069457 | |
| S184 | Phosphorylation | score2 | PhosphoSitePlus | 24197116 | ||
| S184 | Phosphorylation | O14757 (CHEK1) | score2 | PhosphoSitePlus | 24197116 | |
| S197 | Phosphorylation | score2 | PhosphoSitePlus | 18514071 | ||
| S197 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 18514071 | |
| T202 | Phosphorylation | score4 | HPRD neXtProt PhosphoSitePlus | 18691976, 21874044, 17563743, ... | ||
| T202 | Phosphorylation | O14965 (AURKA) | score3 | PhosphoSitePlus | 17563743, 21874044 | |
| T202 | Phosphorylation | Q13043 (STK4) | score2 | neXtProt | 19062280 | |
| S203 | Phosphorylation | score4 | neXtProt PhosphoSitePlus | 18071316, 19062280, 17563743, ... | ||
| S203 | Phosphorylation | O14965 (AURKA) | score3 | PhosphoSitePlus | 17563743, 19276349, 21874044 | |
| S203 | Phosphorylation | P11802 (CDK4) | score2 | PhosphoSitePlus | 18071316 | |
| S203 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 18514071 | |
| S203 | Phosphorylation | P17612 (PRKACA) | score2 | PhosphoSitePlus | 20655196 | |
| S203 | Phosphorylation | Q13043 (STK4) | score2 | neXtProt | 19062280 | |
| S203 | Phosphorylation | Q96GD4 (AURKB) | score2 | PhosphoSitePlus | 19276349 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| R18 | C18 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| R18 | S18 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| R36 | Q36 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| S179 | R179 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| K236 | N236 | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
| K281 | N281 | Biomuta | [ cosmic ] |
