Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9NS23 / RASF1_HUMAN
Protein Name Ras association domain-containing protein 1
Gene Name Name: RASSF1
Organism Homo sapiens (Human)

DAG View
PRO Name Ras association domain-containing protein 1 (human)
Definition A Ras association domain-containing protein 1 that is encoded in the genome of human.
Short Label hRASSF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9NS23 (RASSF1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19369195
S2 Phosphorylation PhosphoSitePlus   UniProt 19369195
R18 Methylation PhosphoSitePlus
K21 Acetylation PhosphoSitePlus
R36 Methylation PhosphoSitePlus   UniProt 24129315
S135 Phosphorylation Q13315 (ATM) neXtProt   PhosphoSitePlus   Signor 10608806, 19962312
K142 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
S188 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   Signor 24197116
R198 Methylation PhosphoSitePlus
T206 Phosphorylation O14965 (AURKA) PhosphoSitePlus   Signor 17563743
S207 Phosphorylation Q96GD4 (AURKB) , P11802 (CDK4) , O14965 (AURKA) neXtProt   PhosphoSitePlus   Signor 18071316, 19276349, 17563743
K216 Ubiquitination PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
Y259 Phosphorylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T206 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
T38 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 24197116
T43 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 24197116
S131 Phosphorylation Q13535 (ATR) , Q13315 (ATM) PhosphoSitePlus 25368379, 19962312
S175 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 20069457
S178 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 20069457
S179 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 20069457
S184 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 24197116
S197 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 18514071
T202 Phosphorylation Q13043 (STK4) , O14965 (AURKA) HPRD   neXtProt   PhosphoSitePlus 18691976, 21874044, 17563743, ...19062280
S203 Phosphorylation Q96GD4 (AURKB) , Q13043 (STK4) , O14965 (AURKA) , P17612 (PRKACA) , P11802 (CDK4) , P17252 (PRKCA) neXtProt   PhosphoSitePlus 18071316, 19062280, 17563743, ...20655196, 19276349, 21874044, 18514071
Site PTM Type PTM Enzyme Score Source PMID
T51 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation Q13535 (ATR) neXtProt 10608806
K68 Ubiquitination PhosphoSitePlus
T132 Phosphorylation HPRD 18691976

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R18 C18 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R18 S18 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K21 Q21 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K236 N236 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]