iPTMnet Report for Q9NRR4 (DROSHA)
Protein Information
UniProt AC / UniProt ID | Q9NRR4 / RNC_HUMAN |
Protein Name | Ribonuclease 3 |
Gene Name | Name: DROSHA Synonyms:RN3,RNASE3L,RNASEN; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9NRR4 |
PRO Name | ribonuclease 3 (human) |
Definition | A ribonuclease 3 that is encoded in the genome of human. |
Short Label | hDROSHA |
Category | organism-gene |
Q9NRR4 (DROSHA) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S221 | Phosphorylation | score2 | PhosphoSitePlus | 25699712 | ||
S221 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 25699712 | |
Y228 | Phosphorylation | score1 | PhosphoSitePlus | |||
S237 | Phosphorylation | score1 | PhosphoSitePlus | |||
S255 | Phosphorylation | score2 | PhosphoSitePlus | 25699712 | ||
S255 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 25699712 | |
S267 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y269 | Phosphorylation | score1 | PhosphoSitePlus | |||
R271 | Methylation | score1 | PhosphoSitePlus | |||
T274 | Phosphorylation | score2 | PhosphoSitePlus | 25699712 | ||
T274 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 25699712 | |
S276 | Phosphorylation | score1 | PhosphoSitePlus | |||
S300 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 20554852, 25699712, 21674040, ... | ||
S300 | Phosphorylation | P49841 (GSK3B) | score2 | PhosphoSitePlus | 21674040 | |
S300 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 25699712 | |
S302 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 20554852, 21674040, 27907888 | ||
S302 | Phosphorylation | P49841 (GSK3B) | score2 | PhosphoSitePlus | 21674040 | |
S317 | Phosphorylation | score1 | PhosphoSitePlus | |||
S355 | Phosphorylation | score4 | PhosphoSitePlus UniProt | 25699712, 23186163 | ||
S355 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 25699712 | |
S357 | Phosphorylation | score1 | PhosphoSitePlus | |||
S373 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 23186163 | ||
K382 | Ubiquitination | score1 | PhosphoSitePlus | |||
K388 | Sumoylation | score1 | PhosphoSitePlus | |||
K409 | Sumoylation | score1 | PhosphoSitePlus | |||
K409 | Ubiquitination | score1 | PhosphoSitePlus | |||
K447 | Ubiquitination | score1 | PhosphoSitePlus | |||
S491 | Phosphorylation | score1 | PhosphoSitePlus | |||
S698 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y705 | Phosphorylation | score1 | PhosphoSitePlus | |||
K738 | Ubiquitination | score1 | PhosphoSitePlus | |||
T747 | Phosphorylation | score1 | PhosphoSitePlus | |||
K748 | Ubiquitination | score1 | PhosphoSitePlus | |||
T768 | Phosphorylation | score1 | IEDB | 35494241 | ||
K792 | Ubiquitination | score1 | PhosphoSitePlus | |||
K795 | Ubiquitination | score1 | PhosphoSitePlus | |||
S796 | Phosphorylation | score1 | PhosphoSitePlus | |||
S807 | Phosphorylation | score1 | PhosphoSitePlus | |||
K809 | Ubiquitination | score1 | PhosphoSitePlus | |||
K827 | Ubiquitination | score1 | PhosphoSitePlus | |||
K831 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1207 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1250 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1262 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1277 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1285 | Ubiquitination | score1 | PhosphoSitePlus | |||
S1293 | Phosphorylation | score1 | PhosphoSitePlus | |||
K1313 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1331 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1341 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1353 | Ubiquitination | score1 | PhosphoSitePlus | |||
K1373 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S237 | Phosphorylation | score0 | HPRD | 20068231 | ||
S284 | Phosphorylation | score0 | HPRD | 17081983 | ||
S355 | Phosphorylation | score0 | HPRD | 19651622, 17081983, 20068231 | ||
S357 | Phosphorylation | score0 | HPRD | 19651622, 17081983, 20068231 | ||
S373 | Phosphorylation | score0 | HPRD | 19651622 | ||
S796 | Phosphorylation | score0 | HPRD | 18491316 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | Q9NRR4 (DROSHA) | S300 | Q92841 (DDX17) | unknown | eFIP | 27907888 | |
Phosphorylation | Q9NRR4 (DROSHA) | S300 | Q8WYQ5 (DGCR8) | unknown | eFIP | 27907888 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S237 | C237 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
R271 | Q271 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
R271 | * | Biomuta | [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
S276 | C276 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S300 | L300 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S302 | C302 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
K382 | N382 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ] | |
K447 | T447 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S698 | F698 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
T747 | M747 | Biomuta | DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
K748 | R748 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K792 | Q792 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K1331 | T1331 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |