Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRR4 / RNC_HUMAN
Protein Name Ribonuclease 3
Gene Name Name: DROSHA
Synonyms:RN3,RNASE3L,RNASEN;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRR4
DAG View
PRO Name ribonuclease 3 (human)
Definition A ribonuclease 3 that is encoded in the genome of human.
Short Label hDROSHA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRR4 (DROSHA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S221 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 25699712
Y228 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S255 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 25699712
S267 Phosphorylation PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
R271 Methylation PhosphoSitePlus
T274 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 25699712
S276 Phosphorylation PhosphoSitePlus
S300 Phosphorylation Q16539 (MAPK14) , P49841 (GSK3B) PhosphoSitePlus   RLIMS-P 20554852, 25699712, 21674040, ...27907888
S302 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P 20554852, 21674040, 27907888
S317 Phosphorylation PhosphoSitePlus
S355 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus   UniProt 25699712, 23186163
S357 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K382 Ubiquitination PhosphoSitePlus
K388 Sumoylation PhosphoSitePlus
K409 Sumoylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
Y705 Phosphorylation PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
T747 Phosphorylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
S796 Phosphorylation PhosphoSitePlus
S807 Phosphorylation PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
K1207 Ubiquitination PhosphoSitePlus
K1250 Ubiquitination PhosphoSitePlus
K1262 Ubiquitination PhosphoSitePlus
K1277 Ubiquitination PhosphoSitePlus
K1285 Ubiquitination PhosphoSitePlus
S1293 Phosphorylation PhosphoSitePlus
K1313 Ubiquitination PhosphoSitePlus
K1331 Ubiquitination PhosphoSitePlus
K1341 Ubiquitination PhosphoSitePlus
K1353 Ubiquitination PhosphoSitePlus
K1373 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S237 Phosphorylation HPRD 20068231
S284 Phosphorylation HPRD 17081983
S355 Phosphorylation HPRD 19651622, 17081983, 20068231
S357 Phosphorylation HPRD 19651622, 17081983, 20068231
S373 Phosphorylation HPRD 19651622
S796 Phosphorylation HPRD 18491316


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9NRR4 (DROSHA) S300 Q92841 (DDX17) unknown eFIP 27907888
Phosphorylation Q9NRR4 (DROSHA) S300 Q8WYQ5 (DGCR8) unknown eFIP 27907888


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S237 C237 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R271 Q271 Biomuta DOID:3571 / liver cancer [ icgc ]
R271 * Biomuta DOID:1909 / melanoma [ cosmic ] DOID:1115 / sarcoma [ tcga ]
S276 C276 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S300 L300 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S302 C302 Biomuta DOID:1324 / lung cancer [ cosmic ]
K382 N382 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K447 T447 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S698 F698 Biomuta DOID:4159 / skin cancer [ icgc ] DOID:1909 / melanoma [ tcga ]
T747 M747 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K809 T809 Biomuta DOID:10534 / stomach cancer [ tcga ]