iPTMnet Report for Q9NRD5 (PICK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRD5 / PICK1_HUMAN
Protein Name PRKCA-binding protein
Gene Name Name: PICK1
Synonyms:PRKCABP;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRD5
DAG View
PRO Name PRKCA-binding protein (human)
Definition A PRKCA-binding protein that is encoded in the genome of human.
Short Label hPICK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRD5 (PICK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation PhosphoSitePlus
S77 Phosphorylation P17252 (PRKCA) RLIMS-P+ 22129425
T82 Phosphorylation RLIMS-P   UniProt 20403402, 17327904
K103 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
S262 Phosphorylation RLIMS-P 15178939
Y285 Phosphorylation PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S342 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 26472923
Y349 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
S411 Phosphorylation PhosphoSitePlus
C413 S-Nitrosylation dbSNO 26338901
S415 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 26472923
Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation HPRD 19413330


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42262 (GRIA2) S880 Q9NRD5 (PICK1) unknown eFIP 22049330
Phosphorylation P78348 (ASIC1) S479 Q9NRD5 (PICK1) inhibited_association eFIP 12578970


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K164 I164 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K209 * Biomuta DOID:4159 / skin cancer [ cosmic ]