iPTMnet Report for Q9NRA0 (SPHK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NRA0 / SPHK2_HUMAN
Protein Name Sphingosine kinase 2
Gene Name Name: SPHK2
Synonyms:SK2;
Organism Homo sapiens (Human)

PRO ID PR:Q9NRA0
DAG View
PRO Name sphingosine kinase 2 (human)
Definition A sphingosine kinase 2 that is encoded in the genome of human.
Short Label hSPHK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NRA0 (SPHK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S105 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
T368 Phosphorylation PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
Y372 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
S387 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor   UniProt 17311928, 23186163
T389 Phosphorylation phospho.ELM 18669648
S399 Phosphorylation PhosphoSitePlus   UniProt 23186163
T402 Phosphorylation PhosphoSitePlus
T404 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S419 Phosphorylation Q15139 (PRKD1) , O94806 (PRKD3) neXtProt   PhosphoSitePlus   UniProt 17635916
S421 Phosphorylation O94806 (PRKD3) , Q15139 (PRKD1) neXtProt   PhosphoSitePlus   UniProt 17635916
S473 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus   UniProt 24275569
S484 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T614 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor   UniProt 17311928
Site PTM Type PTM Enzyme Score Source PMID
S387 Phosphorylation HPRD 18691976
T389 Phosphorylation HPRD 18669648
T404 Phosphorylation HPRD 18691976
S414 Phosphorylation HPRD 18691976
S484 Phosphorylation HPRD 18691976, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S363 Phosphorylation PhosphoSitePlus
T368 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S105 N105 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T359 I359 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y378 S378 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S399 L399 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S419 F419 Biomuta DOID:4159 / skin cancer [ cosmic ]
S484 P484 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]