iPTMnet Report for Q9NRA0 (SPHK2)
Protein Information
| UniProt AC / UniProt ID | Q9NRA0 / SPHK2_HUMAN |
| Protein Name | Sphingosine kinase 2 |
| Gene Name | Name: SPHK2 Synonyms:SK2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9NRA0 |
| PRO Name | sphingosine kinase 2 (human) |
| Definition | A sphingosine kinase 2 that is encoded in the genome of human. |
| Short Label | hSPHK2 |
| Category | organism-gene |
DAG ViewQ9NRA0 (SPHK2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S105 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S107 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S355 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T359 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T368 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T371 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y372 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y378 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S387 | Phosphorylation | score4 | neXtProt PhosphoSitePlus Signor UniProt | 17311928, 23186163 | ||
| S387 | Phosphorylation | P27361 (MAPK3) | score3 | neXtProt PhosphoSitePlus Signor | 17311928 | |
| S387 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus Signor | 17311928 | |
| T389 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
| S399 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| T402 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T404 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S414 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S419 | Phosphorylation | score3 | neXtProt PhosphoSitePlus UniProt | 17635916 | ||
| S419 | Phosphorylation | O94806 (PRKD3) | score2 | neXtProt | 17635916 | |
| S419 | Phosphorylation | Q15139 (PRKD1) | score2 | PhosphoSitePlus | 17635916 | |
| S421 | Phosphorylation | score3 | neXtProt PhosphoSitePlus UniProt | 17635916 | ||
| S421 | Phosphorylation | O94806 (PRKD3) | score2 | neXtProt | 17635916 | |
| S421 | Phosphorylation | Q15139 (PRKD1) | score2 | PhosphoSitePlus | 17635916 | |
| S473 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S477 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S484 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| T614 | Phosphorylation | score3 | neXtProt PhosphoSitePlus Signor UniProt | 17311928 | ||
| T614 | Phosphorylation | P27361 (MAPK3) | score3 | neXtProt PhosphoSitePlus Signor | 17311928 | |
| T614 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus Signor | 17311928 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S387 | Phosphorylation | score0 | HPRD | 18691976 | ||
| T389 | Phosphorylation | score0 | HPRD | 18669648 | ||
| T404 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S414 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S484 | Phosphorylation | score0 | HPRD | 18691976, 18669648 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S363 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T368 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S105 | N105 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| T359 | I359 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| Y378 | S378 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S399 | L399 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S419 | F419 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S484 | P484 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
