Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9NR33 / DPOE4_HUMAN
Protein Name DNA polymerase epsilon subunit 4
Gene Name Name: POLE4
Organism Homo sapiens (Human)

DAG View
PRO Name DNA polymerase epsilon subunit 4 (human)
Definition A DNA polymerase epsilon subunit 4 that is encoded in the genome of human.
Short Label hPOLE4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9NR33 (POLE4) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 20068231
T11 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 20068231
S25 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K51 Sumoylation PhosphoSitePlus
T57 Phosphorylation PhosphoSitePlus
C84 S-Nitrosylation dbSNO 19483679
C85 S-Nitrosylation dbSNO 19483679
K90 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S25 L25 Biomuta DOID:1909 / melanoma [ cosmic ]