iPTMnet Report for Q9NPJ6 (MED4)
Protein Information
| UniProt AC / UniProt ID | Q9NPJ6 / MED4_HUMAN |
| Protein Name | Mediator of RNA polymerase II transcription subunit 4 |
| Gene Name | Name: MED4 Synonyms:ARC36,DRIP36,VDRIP;ORFNames:HSPC126; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9NPJ6 |
| PRO Name | mediator of RNA polymerase II transcription subunit 4 (human) |
| Definition | A mediator of RNA polymerase II transcription subunit 4 that is encoded in the genome of human. |
| Short Label | hMED4 |
| Category | organism-gene |
DAG ViewQ9NPJ6 (MED4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score1 | UniProt | 22814378 | ||
| S32 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195, 19690332 | ||
| K55 | Acetylation | score1 | PhosphoSitePlus | |||
| K55 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K81 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K88 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K98 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K112 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K115 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K129 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S134 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K140 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K150 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| A2 | G2 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| S32 | F32 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
