Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9NPJ6 / MED4_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 4
Gene Name Name: MED4
Synonyms:ARC36,DRIP36,VDRIP;ORFNames:HSPC126;
Organism Homo sapiens (Human)

PRO ID PR:Q9NPJ6
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 4 (human)
Definition A mediator of RNA polymerase II transcription subunit 4 that is encoded in the genome of human.
Short Label hMED4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9NPJ6 (MED4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S32 Phosphorylation PhosphoSitePlus   UniProt 19369195, 19690332
K55 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 G2 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S32 F32 Biomuta DOID:1909 / melanoma [ cosmic ]