iPTMnet Report for Q9NP71 (MLXIPL)
Protein Information
| UniProt AC / UniProt ID | Q9NP71 / MLXPL_HUMAN |
| Protein Name | Carbohydrate-responsive element-binding protein |
| Gene Name | Name: MLXIPL Synonyms:BHLHD14,MIO,WBSCR14; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9NP71 |
| PRO Name | carbohydrate-responsive element-binding protein (human) |
| Definition | A carbohydrate-responsive element-binding protein that is encoded in the genome of human. |
| Short Label | hMLXIPL |
| Category | organism-gene |
DAG ViewQ9NP71 (MLXIPL) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S20 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S23 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S25 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| T27 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S29 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S33 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S37 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S71 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S81 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S140 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P | 18606808, 22506051 | ||
| T147 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K171 | Acetylation | score1 | PhosphoSitePlus | |||
| S196 | Phosphorylation | score4 | PRO PhosphoSitePlus RLIMS-P UniProt | 18606808, 23186163, 23918932, ... | ||
| S196 | Phosphorylation | P17612 (PRKACA) | score2 | PhosphoSitePlus | 23918932 | |
| S499 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T519 | O-Glycosylation | score2 | GlyGen | 28450420 | ||
| S556 | Phosphorylation | score1 | PRO | |||
| S602 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
| S614 | O-Glycosylation | score2 | GlyGen | 28450420 | ||
| S614 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S631 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| T653 | Phosphorylation | score1 | PRO | |||
| S827 | O-Glycosylation | score2 | GlyGen | 28450420 | ||
| T840 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S602 | Phosphorylation | score0 | HPRD | 20166139 | ||
| S614 | Phosphorylation | score0 | HPRD | 20166139 | ||
| T653 | Phosphorylation | score1 | HPRD | 11698644 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S196 | Phosphorylation | score1 | HPRD | 11698644 | ||
| S602 | Phosphorylation | score0 | HPRD | 20166139 | ||
| S614 | Phosphorylation | score0 | HPRD | 20166139 | ||
| T653 | Phosphorylation | score1 | HPRD | 11698644 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000048385 (hMLXIPL/Phos:1) | pS196,pT653 | PRO | |||
| PR:000048386 (hMLXIPL/Phos:2) | pS556 | PRO | |||
| PR:000048387 (hMLXIPL/Phos:3) | pT653 | PRO |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9NP71 (MLXIPL) | S196 | O14980 (XPO1) | unknown | eFIP | 18606808 | |
| Phosphorylation | Q9NP71 (MLXIPL) | S196 | P27348 (YWHAQ) | unknown | eFIP | 32776146 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S29 | L29 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ] | |
| S140 | N140 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] |
