iPTMnet Report Q9HBY8 SGK2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9HBY8 / SGK2_HUMAN
Protein Name	Serine/threonine-protein kinase Sgk2
Gene Name	Name: SGK2
Organism	Homo sapiens (Human)

PRO ID	PR:Q9HBY8 DAG View
PRO Name	serine/threonine-protein kinase Sgk2 (human)
Definition	A serine/threonine-protein kinase Sgk2 that is encoded in the genome of human.
Short Label	hSGK2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9HBY8 (SGK2) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T193	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	26392083, 10548550
	C262	Methylation		score1	IEDB	31844290

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K99	Ubiquitination		score1	PhosphoSitePlus
	S116	Phosphorylation		score1	PhosphoSitePlus
	K124	Ubiquitination		score1	PhosphoSitePlus
	T251	Phosphorylation		score1	PhosphoSitePlus
	T253	Phosphorylation		score1	PhosphoSitePlus
	T257	Phosphorylation		score1	PhosphoSitePlus
	Y285	Phosphorylation		score1	PhosphoSitePlus
	S339	Phosphorylation		score1	PhosphoSitePlus
	T366	Phosphorylation		score1	PhosphoSitePlus
	T374	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T193	Phosphorylation		score1	HPRD	10548550
	T193	Phosphorylation	O15530 (PDPK1)	score1	HPRD	10548550
	S356	Phosphorylation		score1	HPRD	10548550
	S356	Phosphorylation	O15530 (PDPK1)	score1	HPRD	10548550

Q9HBY8 (SGK2) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	O43524 (FOXO3)	T32	score1	Signor	11154281
	O43524 (FOXO3)	S253	score1	Signor	11154281

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K124	N124	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T193	A193	Biomuta		DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T253	A253	Biomuta		DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T257	I257	Biomuta		[ cosmic ]
C262	Y262	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]
S339	F339	Biomuta		[ cosmic ]
S356	F356	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ]
T374	A374	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]