Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9HBY8 / SGK2_HUMAN
Protein Name Serine/threonine-protein kinase Sgk2
Gene Name Name: SGK2
Organism Homo sapiens (Human)

DAG View
PRO Name serine/threonine-protein kinase Sgk2 (human)
Definition A serine/threonine-protein kinase Sgk2 that is encoded in the genome of human.
Short Label hSGK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9HBY8 (SGK2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K99 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
T253 Phosphorylation O15530 (PDPK1) phospho.ELM   PhosphoSitePlus   UniProt 10548550
T257 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T253 Phosphorylation O15530 (PDPK1) HPRD 10548550
S416 Phosphorylation O15530 (PDPK1) HPRD 10548550
Site PTM Type PTM Enzyme Score Source PMID
T193 Phosphorylation O15530 (PDPK1) HPRD   PhosphoSitePlus 10548550
S356 Phosphorylation O15530 (PDPK1) HPRD 10548550

Q9HBY8 (SGK2) as PTM Enzyme

Substrate Site Score Source PMID
O43524 (FOXO3) T32 Signor 11154281
O43524 (FOXO3) S253 Signor 11154281

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K124 N124 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T253 A253 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T374 A374 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S416 F416 Biomuta DOID:1909 / melanoma [ tcga ]