iPTMnet Report for Q9HBA0 (TRPV4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9HBA0 / TRPV4_HUMAN
Protein Name Transient receptor potential cation channel subfamily V member 4
Gene Name Name: TRPV4
Synonyms:VRL2,VROAC;
Organism Homo sapiens (Human)

PRO ID PR:Q9HBA0
DAG View
PRO Name transient receptor potential cation channel subfamily V member 4 (human)
Definition A transient receptor potential cation channel TRPV4 that is encoded in the genome of human.
Short Label hTRPV4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9HBA0 (TRPV4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y91 Phosphorylation PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
T112 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S162 Phosphorylation Q05655 (PRKCD) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   Signor 19661060
T175 Phosphorylation Q05655 (PRKCD) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   Signor 19661060
S189 Phosphorylation P17252 (PRKCA) , Q05655 (PRKCD) phospho.ELM   PhosphoSitePlus   Signor 19661060
Y253 Phosphorylation P07948 (LYN) phospho.ELM 12538589
H265 Dihydroxylation IntAct 21251231
S319 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
Y411 Phosphorylation phospho.ELM 12538589
S470 Phosphorylation PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
Y508 Phosphorylation PhosphoSitePlus
Y805 Phosphorylation PhosphoSitePlus
T813 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
S824 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P 31567350, 33537292, 25972993, ...19661060, 20043876, 35469044, 29462784, 22101010, 23619744
Site PTM Type PTM Enzyme Score Source PMID
Y253 Phosphorylation P07948 (LYN) HPRD 12538589
Y411 Phosphorylation HPRD 12538589
Y508 Phosphorylation HPRD 16964243
Site PTM Type PTM Enzyme Score Source PMID
Y253 Phosphorylation P07948 (LYN) HPRD 12538589
Y448 Phosphorylation HPRD 16964243


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9HBA0 (TRPV4) S824 Q13586 (STIM1) unknown eFIP 25972993


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q9HBA0-1 (hTRPV4/iso:A) Interaction PR:Q9HBA0-1 (hTRPV4/iso:A) PRO 16293632
PR:Q9HBA0-5 (hTRPV4/iso:D) Interaction PR:Q9HBA0-5 (hTRPV4/iso:D) PRO 16293632


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y448 * Biomuta DOID:1324 / lung cancer [ cosmic ]