iPTMnet Report Q9HBA0 TRPV4

Protein Information

UniProt AC / UniProt ID	Q9HBA0 / TRPV4_HUMAN
Protein Name	Transient receptor potential cation channel subfamily V member 4
Gene Name	Name: TRPV4 Synonyms:VRL2,VROAC;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9HBA0 DAG View
PRO Name	transient receptor potential cation channel subfamily V member 4 (human)
Definition	A transient receptor potential cation channel TRPV4 that is encoded in the genome of human.
Short Label	hTRPV4
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9HBA0 (TRPV4) as Substrate

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position Y91 Y110 T112 Y113 S134 S162 T175 S189 Y253 H265 S319 T335 K344 Y411 S470 T505 Y508 Y805 T813 S823 S824	PTM Type Select all Dihydroxylation Phosphorylation Ubiquitination	PTM Enzyme Select all P07948 (LYN) P17252 (PRKCA) P17612 (PRKACA) Q05655 (PRKCD)	Score Select all 1 2 3 4	Source Select all IntAct PhosphoSitePlus RLIMS-P Signor phospho.ELM	PMID
Y91	Phosphorylation		score1	PhosphoSitePlus
Y110	Phosphorylation		score1	PhosphoSitePlus
T112	Phosphorylation		score1	PhosphoSitePlus
Y113	Phosphorylation		score1	PhosphoSitePlus
S134	Phosphorylation		score1	PhosphoSitePlus
S162	Phosphorylation		score3	phospho.ELM PhosphoSitePlus Signor	19661060
S162	Phosphorylation	P17252 (PRKCA)	score1	Signor	19661060
S162	Phosphorylation	Q05655 (PRKCD)	score2	PhosphoSitePlus	19661060
T175	Phosphorylation		score3	phospho.ELM PhosphoSitePlus Signor	19661060
T175	Phosphorylation	P17252 (PRKCA)	score1	Signor	19661060
T175	Phosphorylation	Q05655 (PRKCD)	score2	PhosphoSitePlus	19661060
S189	Phosphorylation		score3	phospho.ELM PhosphoSitePlus Signor	19661060
S189	Phosphorylation	P17252 (PRKCA)	score1	Signor	19661060
S189	Phosphorylation	Q05655 (PRKCD)	score2	PhosphoSitePlus	19661060
Y253	Phosphorylation		score2	phospho.ELM	12538589
Y253	Phosphorylation	P07948 (LYN)	score2	phospho.ELM	12538589
H265	Dihydroxylation		score2	IntAct	21251231
S319	Phosphorylation		score1	PhosphoSitePlus
T335	Phosphorylation		score1	PhosphoSitePlus
K344	Ubiquitination		score1	PhosphoSitePlus
Y411	Phosphorylation		score2	phospho.ELM	12538589
S470	Phosphorylation		score1	PhosphoSitePlus
T505	Phosphorylation		score1	PhosphoSitePlus
Y508	Phosphorylation		score1	PhosphoSitePlus
Y805	Phosphorylation		score1	PhosphoSitePlus
T813	Phosphorylation		score1	PhosphoSitePlus
S823	Phosphorylation		score1	PhosphoSitePlus
S824	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P	31567350, 33537292, 25972993, ...19661060, 20043876, 35469044, 29462784, 22101010, 23619744
S824	Phosphorylation	P17612 (PRKACA)	score2	PhosphoSitePlus	19661060

Search:

Site Select all By amino acid All Tyrosine By position Y253 Y411 Y508	PTM Type Select all Phosphorylation	PTM Enzyme Select all P07948 (LYN)	Score Select all 0 1	Source Select all HPRD	PMID
Y253	Phosphorylation		score1	HPRD	12538589
Y253	Phosphorylation	P07948 (LYN)	score1	HPRD	12538589
Y411	Phosphorylation		score1	HPRD	12538589
Y508	Phosphorylation		score0	HPRD	16964243

Search:

Site Select all By amino acid All Tyrosine By position Y253 Y448	PTM Type Select all Phosphorylation	PTM Enzyme Select all P07948 (LYN)	Score Select all 0 1	Source Select all HPRD	PMID
Y253	Phosphorylation		score1	HPRD	12538589
Y253	Phosphorylation	P07948 (LYN)	score1	HPRD	12538589
Y448	Phosphorylation		score0	HPRD	16964243

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all Q9HBA0 (TRPV4)	Site Select all By amino acid All Serine By position S824	Interactant Select all Q13586 (STIM1)	Association type Select all unknown	Source Select all eFIP	PMID
	Phosphorylation	Q9HBA0 (TRPV4)	S824	Q13586 (STIM1)	unknown	eFIP	25972993

Proteoform PPIs

Search:

	Protein 1 Select all PR:Q9HBA0-1 (hTRPV4/iso:A) PR:Q9HBA0-5 (hTRPV4/iso:D)	Relation Select all Interaction	Protein 2 Select all PR:Q9HBA0-1 (hTRPV4/iso:A) PR:Q9HBA0-5 (hTRPV4/iso:D)	Source Select all PRO	PMID
	PR:Q9HBA0-1 (hTRPV4/iso:A)	Interaction	PR:Q9HBA0-1 (hTRPV4/iso:A)	PRO	16293632
	PR:Q9HBA0-5 (hTRPV4/iso:D)	Interaction	PR:Q9HBA0-5 (hTRPV4/iso:D)	PRO	16293632

PTM sites affected in variants

Search:

Site Select all By amino acid All Tyrosine By position Y448	Variant Select all *	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:1324 / lung cancer [ cosmic ]
Y448	*	Biomuta		DOID:1324 / lung cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q9HBA0 (TRPV4)

Protein Information

Interactive Sequence View

Q9HBA0 (TRPV4) as Substrate

PTM-dependent PPI

Proteoform PPIs

PTM sites affected in variants