Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9HA77 / SYCM_HUMAN
Protein Name Probable cysteine--tRNA ligase, mitochondrial precursor
Gene Name Name: CARS2
Organism Homo sapiens (Human)

DAG View
PRO Name probable cysteine--tRNA ligase, mitochondrial (human)
Definition A probable cysteine--tRNA ligase, mitochondrial that is encoded in the genome of human.
Short Label hCARS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9HA77 (CARS2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T46 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K223 Acetylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
K329 Acetylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
T416 Phosphorylation PhosphoSitePlus
T534 Phosphorylation HPRD   PhosphoSitePlus 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S111 N111 Biomuta DOID:363 / uterine cancer [ tcga ]
T160 M160 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T416 K416 Biomuta DOID:3571 / liver cancer [ icgc ]
T534 N534 Biomuta DOID:3571 / liver cancer [ icgc ]
T534 I534 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]