iPTMnet Report for Q9H9S0 (NANOG)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H9S0 / NANOG_HUMAN
Protein Name Homeobox protein NANOG
Gene Name Name: NANOG
Organism Homo sapiens (Human)

PRO ID PR:Q9H9S0
DAG View
PRO Name homeobox protein NANOG (human)
Definition A homeobox protein NANOG that is encoded in the genome of human.
Short Label hNANOG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H9S0 (NANOG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation RLIMS-P 21969378
Y35 Phosphorylation Q05397 (PTK2) neXtProt   PhosphoSitePlus 22493428
T50 Phosphorylation PhosphoSitePlus
S52 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 24793005, 24678451
S56 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus   RLIMS-P 28457890
S68 Phosphorylation PhosphoSitePlus   RLIMS-P 30595535
T70 Phosphorylation PhosphoSitePlus
S71 Phosphorylation P28482 (MAPK1) , P06493 (CDK1) neXtProt   PhosphoSitePlus 24793005, 24678451
T78 Phosphorylation Q02156 (PRKCE) , P28482 (MAPK1) neXtProt   PhosphoSitePlus 24793005, 23708658
S79 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus 23708658
S135 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus 23708658
Y174 Phosphorylation Q05397 (PTK2) neXtProt   PhosphoSitePlus 22493428
T200 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus   RLIMS-P 23708658
S258 Phosphorylation PhosphoSitePlus
T280 Phosphorylation Q02156 (PRKCE) PhosphoSitePlus   RLIMS-P 23708658
T286 Phosphorylation PhosphoSitePlus
T289 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9H9S0 (NANOG) S68 O43791 (SPOP) inhibited_association eFIP 30595535
Phosphorylation Q9H9S0 (NANOG) T200 Q09472 (EP300) unknown eFIP 23708658


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y35 H35 Biomuta DOID:3571 / liver cancer [ cosmic ]
T50 N50 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S52 T52 Biomuta DOID:1324 / lung cancer [ cosmic ]
S65 N65 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S68 Y68 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T70 P70 Biomuta DOID:3571 / liver cancer [ cosmic ]
T78 I78 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]