iPTMnet Report for Q9H9S0 (NANOG)
Protein Information
| UniProt AC / UniProt ID | Q9H9S0 / NANOG_HUMAN |
| Protein Name | Homeobox protein NANOG |
| Gene Name | Name: NANOG |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9H9S0 |
| PRO Name | homeobox protein NANOG (human) |
| Definition | A homeobox protein NANOG that is encoded in the genome of human. |
| Short Label | hNANOG |
| Category | organism-gene |
DAG ViewQ9H9S0 (NANOG) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score0 | RLIMS-P | 21969378 | ||
| Y35 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 22493428 | ||
| Y35 | Phosphorylation | Q05397 (PTK2) | score3 | neXtProt PhosphoSitePlus | 22493428 | |
| T50 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S52 | Phosphorylation | score4 | neXtProt PhosphoSitePlus | 24793005, 24678451 | ||
| S52 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt | 24793005, 24678451 | |
| S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S57 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S65 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 28457890 | ||
| S68 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 30595535 | ||
| T70 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S71 | Phosphorylation | score4 | neXtProt PhosphoSitePlus | 24793005, 24678451 | ||
| S71 | Phosphorylation | P06493 (CDK1) | score2 | neXtProt | 24678451 | |
| S71 | Phosphorylation | P28482 (MAPK1) | score2 | neXtProt | 24793005 | |
| T78 | Phosphorylation | score4 | neXtProt PhosphoSitePlus | 24793005, 23708658 | ||
| T78 | Phosphorylation | P28482 (MAPK1) | score2 | neXtProt | 24793005 | |
| T78 | Phosphorylation | Q02156 (PRKCE) | score2 | PhosphoSitePlus | 23708658 | |
| S79 | Phosphorylation | score2 | PhosphoSitePlus | 23708658 | ||
| S79 | Phosphorylation | Q02156 (PRKCE) | score2 | PhosphoSitePlus | 23708658 | |
| S135 | Phosphorylation | score2 | PhosphoSitePlus | 23708658 | ||
| S135 | Phosphorylation | Q02156 (PRKCE) | score2 | PhosphoSitePlus | 23708658 | |
| Y174 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 22493428 | ||
| Y174 | Phosphorylation | Q05397 (PTK2) | score3 | neXtProt PhosphoSitePlus | 22493428 | |
| T200 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 23708658 | ||
| T200 | Phosphorylation | Q02156 (PRKCE) | score2 | PhosphoSitePlus | 23708658 | |
| S258 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T280 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 23708658 | ||
| T280 | Phosphorylation | Q02156 (PRKCE) | score2 | PhosphoSitePlus | 23708658 | |
| T286 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T289 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9H9S0 (NANOG) | S68 | O43791 (SPOP) | inhibited_association | eFIP | 30595535 | |
| Phosphorylation | Q9H9S0 (NANOG) | T200 | Q09472 (EP300) | unknown | eFIP | 23708658 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y35 | H35 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T50 | N50 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S52 | T52 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S65 | N65 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S68 | Y68 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| T70 | P70 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| T78 | I78 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] |
